SynthesisRespirology (Carlton, Vic.)2016
Prognostic value of procalcitonin in pneumonia: A systematic review and meta-analysis.
Synthesis in Respirology (Carlton, Vic.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03711227 (Procalcitonin at Zero and 24 Hours as a Prognostic Factor in Patients With Pneumonia), which is not on this map. Cited by 40 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Procalcitonin at Zero and 24 Hours as a Prognostic Factor in Patients With Pneumonia
Who cites it
40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Pooled it
- Value of D-dimer in predicting various clinical outcomes following community-acquired pneumonia: A network meta-analysis.PloS one · 2022Pooled it
- Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19: A Meta-Analysis Based on 10 Cohort Studies.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Procalcitonin in the Assessment of Ventilator Associated Pneumonia: A Systematic Review.Advances in experimental medicine and biology · 2021Pooled it
- Clinical features for diagnosis of pneumonia among adults in primary care setting: A systematic and meta-review.Scientific reports · 2019Pooled it
- Procalcitonin as a Biomarker in Rhinosinusitis: A Systematic Review.American journal of rhinology & allergy · 2019Pooled it
- Serum soluble urokinase-type plasminogen activator receptor as a biological marker of bacterial infection in adults: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Review
- Baseline Predictors of Adverse Outcome and Survival in Adults Hospitalized with Invasive Pneumococcal Disease.Healthcare (Basel, Switzerland) · 2026Article
- Clinical assessment and biomarkers for the detection of bacterial community-acquired pneumonia in children and adults: a protocol for systematic review of diagnostic accuracy.Systematic reviews · 2026Article
- Biomarkers for pneumonia after major trauma: A systematic review and meta-analysis.Journal of the Intensive Care Society · 2026Article
- Systemic Inflammatory Indices (SII and SIRI) in 30-Day Mortality Risk Stratification for Community-Acquired Pneumonia: A Study Alongside CURB-65 and PSI.Pathogens (Basel, Switzerland) · 2025Article
- Time-dependent variation in immunoparalysis biomarkers among patients with sepsis and critical illness.Frontiers in immunology · 2024Article
- Microbial signatures predictive of short-term prognosis in severe pneumonia.Frontiers in cellular and infection microbiology · 2024Article
- CD4Immunity, inflammation and disease · 2023Article
- Analysis of risk factors for negative emotions in patients with severe pneumonia and their impact on prognosis.Journal of thoracic disease · 2023Article
- Acute Infections and Inflammatory Biomarkers in Patients with Acute Pulmonary Embolism.Journal of clinical medicine · 2023Article
- Lysophosphatidylcholine acyltransferase level predicts the severity and prognosis of patients with community-acquired pneumonia: a prospective multicenter study.Frontiers in immunology · 2023Observational
- The Predictive Value of PCT and Other Infection Indicators in Postoperative Infection of Epithelial Ovarian Cancer.Infection and drug resistance · 2023Article
- Clinical significance of procalcitonin in critically ill patients with pneumonia receiving bronchoalveolar lavage.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis was performed to determine the accuracy of procalcitonin (PCT) in predicting mortality in pneumonia patients with different pathogenic features and disease severities. A systematic search of English-language articles was performed using PubMed, Embase, Web of Knowledge and the Cochrane Library to identify studies. The diagnostic value of PCT in predicting prognosis was determined using a bivariate meta-analysis model. The Q-test and I(2) index were used to test heterogeneity. A total of 21 studies comprising 6007 patients were included. An elevated PCT level was a risk factor for death from community-acquired pneumonia (CAP) (risk ratio (RR) 4.38, 95% confidence interval (CI) 2.98-6.43), particularly in patients with a low CURB-65 score. The commonly used cut-off, 0.5 ng/mL, had low sensitivity (SEN) and was not able to identify patients at high risk of dying. Furthermore, the PCT assay with functional SEN <0.1 ng/mL was necessary to predict mortality in CAP in the clinic. For critically ill patients, an elevated PCT level was associated with an increased risk of mortality (RR 4.18, 95% CI: 3.19-5.48). The prognostic performance was nearly equal between patients with ventilator-associated pneumonia (VAP) and patients with CAP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.