ArticleJournal of biomedical optics2015
Rapid prototyping of biomimetic vascular phantoms for hyperspectral reflectance imaging.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Medical hyperspectral imaging: an updated review of technology advancements and biomedical applications.Journal of biomedical optics · 2026Pooled it
- A diffusion-based 3D printing strategy to fabricate self-supporting, perfusable networks.BMC methods · 2026Review
- Evaluating the Performance of Hyperspectral Imaging Endoscopes: Mitigating Parameters Affecting Spectral Accuracy.Biosensors · 2025Article
- Development of a dynamic pulsatile phantom for the photoplethysmographic waveform at the radial artery.Journal of biomedical optics · 2025Article
- Human Skin Models in Biophotonics: Materials, Methods, and Applications.Advanced healthcare materials · 2025Review
- Anthropomorphic tissue-mimicking phantoms for oximetry validation in multispectral optical imaging.Journal of biomedical optics · 2025Article
- Retina Phantom Model for Hyperspectral Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Effects of phantom microstructure on their optical properties.Journal of biomedical optics · 2024Article
- Rapid prototyping of a retinal multivascular network phantom for optical retinal vascular imaging equipment evaluation.Biomedical optics express · 2024Article
- Compact and ultracompact spectral imagers: technology and applications in biomedical imaging.Journal of biomedical optics · 2023Review
- 3D-printed tissue-simulating phantoms for near-infrared fluorescence imaging of rheumatoid diseases.Journal of biomedical optics · 2022Article
- Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation.Nature biomedical engineering · 2022Review
- Monte-Carlo simulation and tissue-phantom model for validation of ocular oximetry.Biomedical optics express · 2022Article
- Polyacrylamide hydrogel phantoms for performance evaluation of multispectral photoacoustic imaging systems.Photoacoustics · 2021Article
- Performance test methods for near-infrared fluorescence imaging.Medical physics · 2020Article
- Surgical spectral imaging.Medical image analysis · 2020Review
- Optical properties of PlatSil SiliGlass tissue-mimicking phantoms.Biomedical optics express · 2020Article
- Indocyanine green matching phantom for fluorescence-guided surgery imaging system characterization and performance assessment.Journal of biomedical optics · 2020Article
- Cerebral oximetry performance testing with a 3D-printed vascular array phantom.Biomedical optics express · 2019Article
- Discovering new 3D bioprinting applications: Analyzing the case of optical tissue phantoms.International journal of bioprinting · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emerging technique of rapid prototyping with three-dimensional (3-D) printers provides a simple yet revolutionary method for fabricating objects with arbitrary geometry. The use of 3-D printing for generating morphologically biomimetic tissue phantoms based on medical images represents a potentially major advance over existing phantom approaches. Toward the goal of image-defined phantoms, we converted a segmented fundus image of the human retina into a matrix format and edited it to achieve a geometry suitable for printing. Phantoms with vessel-simulating channels were then printed using a photoreactive resin providing biologically relevant turbidity, as determined by spectrophotometry. The morphology of printed vessels was validated by x-ray microcomputed tomography. Channels were filled with hemoglobin (Hb) solutions undergoing desaturation, and phantoms were imaged with a near-infrared hyperspectral reflectance imaging system. Additionally, a phantom was printed incorporating two disjoint vascular networks at different depths, each filled with Hb solutions at different saturation levels. Light propagation effects noted during these measurements—including the influence of vessel density and depth on Hb concentration and saturation estimates, and the effect of wavelength on vessel visualization depth—were evaluated. Overall, our findings indicated that 3-D-printed biomimetic phantoms hold significant potential as realistic and practical tools for elucidating light–tissue interactions and characterizing biophotonic system performance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.