ArticleThe Journal of nutrition2016
Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska.
Article in The Journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Vitamin Metabolism and Its Dependency on Genetic Variations Among Healthy Adults: A Systematic Review for Precision Nutrition Strategies.Nutrients · 2025Pooled it
- Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review.Nutrients · 2021Pooled it
- Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2020Pooled it
- Circulating Vitamin D and Overall Survival in Breast Cancer Patients: A Dose-Response Meta-Analysis of Cohort Studies.Integrative cancer therapies · 2018Pooled it
- Demographic and cultural correlates of traditional eating among Alaska Native adults at risk for cardiovascular disease.PloS one · 2022Trial
- Protocol for improving equity in quantitative big data cleaning: lessons from longitudinal analysis of electronic health records from underrepresented and marginalized communities.International journal of epidemiology · 2025Article
- Diet quality is positively associated with intake of traditional foods and does not differ by season in remote Yup'ik communities.International journal of circumpolar health · 2023Article
- Article
- Tribal Deliberations about Precision Medicine Research: Addressing Diversity and Inequity in Democratic Deliberation Design and Evaluation.Journal of empirical research on human research ethics : JERHRE · 2022Article
- Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function.Clinical and translational science · 2021Observational
- Advancing precision public health using human genomics: examples from the field and future research opportunities.Genome medicine · 2021Article
- The Nitrogen Isotope Ratio Is a Biomarker of Yup'ik Traditional Food Intake and Reflects Dietary Seasonality in Segmental Hair Analyses.The Journal of nutrition · 2019Article
- Negative Impact of 25-hydroxyvitamin D Deficiency on Breast Cancer Survival.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Association of Maternal Vitamin D Deficiency with Early Childhood Caries.Journal of dental research · 2019Article
- Familial clustering of vitamin D deficiency via shared environment: The Korean National Health and Nutrition Examination Survey 2008-2012.European journal of clinical nutrition · 2018Article
- Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska.Molecular nutrition & food research · 2018Article
- A time for everything and everything in its time - exploring the mechanisms underlying seasonality of COPD exacerbations.International journal of chronic obstructive pulmonary disease · 2018Review
- Concerning the vitamin D reference range: pre-analytical and analytical variability of vitamin D measurement.Biochemia medica · 2017Review
- Declines in traditional marine food intake and vitamin D levels from the 1960s to present in young Alaska Native women.Public health nutrition · 2017Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLow blood vitamin D concentration is a concern for people living in circumpolar regions, where sunlight is insufficient for vitamin D synthesis in winter months and the consumption of traditional dietary sources of vitamin D is decreasing.
objectiveThe objective was to characterize the effects of diet, genetic variation, and season on serum 25-hydroxycholecalciferol [25(OH)D3] concentrations in Yup'ik Alaska Native people living in rural southwest Alaska.
methodsThis study was a cross-sectional design that assessed the associations of traditional diet (via a biomarker, the RBC δ(15)N value), age, gender, body mass index (BMI), community location, and genotype of select single nucleotide polymorphisms (SNPs) in cytochrome P450 family 2, subfamily R, peptide 1 (CYP2R1), 7-dehydrocholesterol reductase (DHCR7), and vitamin D binding protein (GC) with serum 25(OH)D3 concentrations in 743 Yup'ik male and female participants, aged 14-93 y, recruited between September 2009 and December 2013.
resultsYup'ik participants, on average, had adequate concentrations of serum 25(OH)D3 (31.1 ± 1.0 ng/mL). Variations in diet, BMI, age, gender, season of sample collection, and inland or coastal community geography were all significantly associated with serum 25(OH)D3 concentration. In models not adjusting for other covariates, age, diet, and seasonal effects explained 33.7%, 20.7%, and 9.8%, respectively, of variability in serum 25(OH)D3 concentrations. Of the 8 SNPs interrogated in CYP2R1 and DHCR7, only rs11023374 in CYP2R1 was significantly associated with serum 25(OH)D3, explaining 1.5% of variability. The GC haplotype explained an additional 2.8% of variability. Together, age, diet, gender, season of sample collection, BMI, geography of the community, and genotype at rs11023374 explained 52.5% of the variability in serum 25(OH)D3 concentrations.
conclusionsLower consumption of the traditional diet was associated with lower serum concentrations of 25(OH)D3. Younger adults and youth in this community may be at increased risk of adverse outcomes associated with vitamin D insufficiency compared with older members of the community, especially during seasons of low sunlight exposure, because of lower consumption of dietary sources of vitamin D.
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