Evidence map›Paper›PMID 26661752›Full record

ArticlePloS one2015

Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation.

Marta Muñoz-Barrera, Isabel Aguilar, Fernando Monje-Casas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Marta Muñoz-BarreraCABIMER, Consejo Superior de Investigaciones Científicas (CSIC), Sevilla, Spain.
Isabel AguilarDepartamento de Genética, Universidad de Sevilla, Sevilla, Spain.
Fernando Monje-CasasCABIMER, Consejo Superior de Investigaciones Científicas (CSIC), Sevilla, Spain.
Centro Andaluz de Biología Molecular y Medicina Regenerativa · ESConsejo Superior de Investigaciones Científicas · ESUniversidad de Sevilla · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aurora B and the spindle assembly checkpoint (SAC) collaborate to ensure the proper biorientation of chromosomes during mitosis. However, lack of Aurora B activity and inactivation of the SAC have a very different impact on chromosome segregation. This is most evident in Saccharomyces cerevisiae, since in this organism the lack of Aurora B is lethal and leads to severe aneuploidy problems, while the SAC is dispensable under normal growth conditions and mutants in this checkpoint do not show evident chromosome segregation defects. We demonstrate that the efficient repair of incorrect chromosome attachments by Aurora B during the initial stages of spindle assembly in budding yeast determines the lack of chromosome segregation defects in SAC mutants, and propose that the differential time window that Aurora B kinase requires to establish chromosome biorientation is the key factor that determines why some cells are more dependent on a functional SAC than others.

Indexed as

AllelesAurora Kinase BAurora KinasesChromosome PositioningChromosome SegregationMicroscopy, FluorescenceMitosisM Phase Cell Cycle CheckpointsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAurora Kinase BAurora KinasesIPL1 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID26661752
PMCPMC4682840
OpenAlexW2300237204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.