ArticleMolecular ecology2015
Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations.
Article in Molecular ecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Environmental coupling of heritability and selection is rare and of minor evolutionary significance in wild populations.Nature ecology & evolution · 2018Pooled it
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- Genetics of flight in spongy moths (Lymantria dispar ssp.): functionally integrated profiling of a complex invasive trait.BMC genomics · 2024Article
- Genetic architecture of dispersal behaviour in the post-harvest pest and model organism Tribolium castaneum.Heredity · 2023Article
- A polygenic basis for birth weight in a wild population of red deer (Cervus elaphus).G3 (Bethesda, Md.) · 2023Article
- Variation in DNA Methylation in Avian Nestlings Is Largely Determined by Genetic Effects.Molecular biology and evolution · 2023Article
- Taking quantitative genomics into the wild.Proceedings. Biological sciences · 2022Article
- Decomposing phenotypic skew and its effects on the predicted response to strong selection.Nature ecology & evolution · 2022Article
- On the genetic architecture of rapidly adapting and convergent life history traits in guppies.Heredity · 2022Article
- Genetics and Plasticity Are Responsible for Ecogeographical Patterns in a Recent Invasion.Frontiers in genetics · 2022Article
- Fur colour in the Arctic fox: genetic architecture and consequences for fitness.Proceedings. Biological sciences · 2021Article
- Admixture mapping reveals loci for carcass mass in red deer x sika hybrids in Kintyre, Scotland.G3 (Bethesda, Md.) · 2021Article
- Heterogeneous selection on exploration behavior within and among West European populations of a passerine bird.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic variation for adaptive traits is associated with polymorphic inversions inEvolution letters · 2021Article
- Epigenetics of Animal Personality: DNA Methylation Cannot Explain the Heritability of Exploratory Behavior in a Songbird.Integrative and comparative biology · 2020Article
- The methylation landscape and its role in domestication and gene regulation in the chicken.Nature ecology & evolution · 2020Article
- The March of the Beetles: Epistatic Components Dominate Divergence in Dispersal Tendency in Tribolium castaneum.The Journal of heredity · 2020Article
- Polygenic basis for adaptive morphological variation in a threatened Aotearoa | New Zealand bird, the hihi (Proceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Currently, there is much debate on the genetic architecture of quantitative traits in wild populations. Is trait variation influenced by many genes of small effect or by a few genes of major effect? Where is additive genetic variation located in the genome? Do the same loci cause similar phenotypic variation in different populations? Great tits (Parus major) have been studied extensively in long-term studies across Europe and consequently are considered an ecological 'model organism'. Recently, genomic resources have been developed for the great tit, including a custom SNP chip and genetic linkage map. In this study, we used a suite of approaches to investigate the genetic architecture of eight quantitative traits in two long-term study populations of great tits--one in the Netherlands and the other in the United Kingdom. Overall, we found little evidence for the presence of genes of large effects in either population. Instead, traits appeared to be influenced by many genes of small effect, with conservative estimates of the number of contributing loci ranging from 31 to 310. Despite concordance between population-specific heritabilities, we found no evidence for the presence of loci having similar effects in both populations. While population-specific genetic architectures are possible, an undetected shared architecture cannot be rejected because of limited power to map loci of small and moderate effects. This study is one of few examples of genetic architecture analysis in replicated wild populations and highlights some of the challenges and limitations researchers will face when attempting similar molecular quantitative genetic studies in free-living populations.
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