Evidence map›Paper›PMID 26661481›Full record

ReviewJournal of child neurology2016

Noninvasive Brain Stimulation in Pediatric Attention-Deficit Hyperactivity Disorder (ADHD): A Review.

Belen Rubio, Aaron D Boes, Simon Laganiere, Alexander Rotenberg, Danique Jeurissen, Alvaro Pascual-Leone

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Journal of child neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06069323 (Therapeutic Use of Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06069323 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.

TypeinterventionalSponsorOspedali Riuniti di FoggiaRan2023 to 2026Enrolled80ConditionsAutism Spectrum Disorder, ADHD, Neurodevelopmental DisordersArmsrepetitive Transcranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. The SASOP/PsychMg child and adolescent attention-deficit/hyperactivity disorder guidelines.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025
    Article
  10. Neuromodulation as a Potential Intervention for Children With Attention-Deficit/Hyperactivity Disorder.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2025
    Article
  11. Article
  12. Biomarkers Obtained by Transcranial Magnetic Stimulation in Neurodevelopmental Disorders.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Clarifying cognitive control and the controllable connectome.Wiley interdisciplinary reviews. Cognitive science · 2019
    Review
  19. Article
  20. Neuroethics of Neuromodulation: An Update.Current opinion in biomedical engineering · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Belen RubioChild and Adolescent Psychiatry Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain Both are co-primary authors.
Aaron D BoesBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA Harvard Medical School, Department of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA Both are co-primary authors. rubiobelen@gmail.com aboes@partners.org.
Simon LaganiereBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
Alexander RotenbergBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA Pediatric Neuromodulation Program, Division of Epilepsy and Neurophysiology, Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Danique JeurissenBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Vision and Cognition, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Alvaro Pascual-LeoneBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
Berenson Allen Center for Noninvasive Brain Stimulation · USBeth Israel Deaconess Medical Center · USHospital Universitario de Canarias · ESRoyal Netherlands Academy of Arts and Sciences · NL

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Neuroscience Resident Research ProgramR25NS065743 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, WILLIAMS, ZIV · 2009 to 2023
$11.8M
Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Mapping progressive loss of intracortical inhibition by TMS and EEG in posttraumatic epileptogenesisR01NS088583 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROTENBERG, ALEXANDER · 2015 to 2019
$1.9M
Cortical connectivity, physiology, and response to stimulation in human epilepsyR01NS073601 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHANG, BERNARD S. · 2011 to 2015
$1.9M
Role of functional brain connectivity on efficacy of TMS for depressionR21MH099196 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$491k
Cortical plasticity in type II diabetes mellitusR21NS082870 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$490k
Transcranial Stimulation in Spino-Cerebellar AtaxiaR21NS085491 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$469k
TEMPERATURE-SENSITIVE GNRH CELL LINESF32HD007616 · NICHD · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MOENTER, SUZANNE M · 1992 to 1994
–
NCRR NIH HHS UL1 RR025758NICHD NIH HHS R01HD069776NICHD NIH HHS R21 HD07616NIMH NIH HHS R21 MH099196NINDS NIH HHS R01NS073601NINDS NIH HHS R01 NS088583NINDS NIH HHS R21 NS082870NINDS NIH HHS R21 NS085491NINDS NIH HHS R25 NS065743NINDS NIH HHS R25NS065743-05PHS HHS R01 100186
6 · The paper itself

Abstract

Attention-deficit hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders in the pediatric population. The clinical management of ADHD is currently limited by a lack of reliable diagnostic biomarkers and inadequate therapy for a minority of patients who do not respond to standard pharmacotherapy. There is optimism that noninvasive brain stimulation may help to address these limitations. Transcranial magnetic stimulation and transcranial direct current stimulation are 2 methods of noninvasive brain stimulation that modulate cortical excitability and brain network activity. Transcranial magnetic stimulation can be used diagnostically to probe cortical neurophysiology, whereas daily use of repetitive transcranial magnetic stimulation or transcranial direct current stimulation can induce long-lasting and potentially therapeutic changes in targeted networks. In this review, we highlight research showing the potential diagnostic and therapeutic applications of transcranial magnetic stimulation and transcranial direct current stimulation in pediatric ADHD. We also discuss the safety and ethics of using these tools in the pediatric population.

Indexed as

Attention Deficit Disorder with HyperactivityBrainHumansPediatricsTranscranial Direct Current StimulationTranscranial Magnetic StimulationADHDneuromodulationpediatrictranscranial direct current stimulationtranscranial magnetic stimulation

Identifiers

PMID26661481
PMCPMC4833526
OpenAlexW2213277078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.