ArticleEvolution; international journal of organic evolution2016
Host population bottlenecks drive parasite extinction during antagonistic coevolution.
Article in Evolution; international journal of organic evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 43 citations in OpenAlex.
- Host Co-Occurrence and Population Size Explain Genetic Differentiation and Diversity in Seal Lice.Molecular ecology · 2025Article
- Boom-Bust Cycles Constrain Host-Parasite Dynamics, Suppress Parasite Spread, and Drive Parasites Extinct.The American naturalist · 2025Article
- Bacteria-phage coevolution with a seed bank.The ISME journal · 2023Article
- Population size impacts host-pathogen coevolution.Proceedings. Biological sciences · 2021Article
- Intrahost speciations and host switches played an important role in the evolution of herpesviruses.Virus evolution · 2021Article
- CRISPR evolution and bacteriophage persistence in the context of population bottlenecks.RNA biology · 2019Article
- Host-pathogen coevolution in the presence of predators: fluctuating selection and ecological feedbacks.Proceedings. Biological sciences · 2018Article
- Article
- Ecological conditions determine extinction risk in co-evolving bacteria-phage populations.BMC evolutionary biology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Host-parasite interactions are often characterized by large fluctuations in host population size, and we investigated how such host bottlenecks affected coevolution between a bacterium and a virus. Previous theory suggests that host bottlenecks should provide parasites with an evolutionary advantage, but instead we found that phages were rapidly driven to extinction when coevolving with hosts exposed to large genetic bottlenecks. This was caused by the stochastic loss of sensitive bacteria, which are required for phage persistence and infectivity evolution. Our findings emphasize the importance of feedbacks between ecological and coevolutionary dynamics, and how this feedback can qualitatively alter coevolutionary dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.