Evidence map›Paper›PMID 26661246›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016

Spreading depolarizations increase delayed brain injury in a rat model of subarachnoid hemorrhage.

Arend M Hamming, Marieke J H Wermer, S Umesh Rudrapatna, Christian Lanier, Hine J A van Os, Walter M van den Bergh, Michel D Ferrari, Annette van der Toorn, Arn M J M van den Maagdenberg, Ann M Stowe and 1 more

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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Conditioning-based therapeutics for aneurysmal subarachnoid hemorrhage - A critical review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Aneurysmal Subarachnoid Hemorrhage: an Overview of Inflammation-Induced Cellular Changes.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  13. Spreading Depolarizations and Subarachnoid Hemorrhage.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  14. Impaired meningeal lymphatic vessel development worsens stroke outcome.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  15. Review
  16. Article
  17. Epileptiform abnormalities predict delayed cerebral ischemia in subarachnoid hemorrhage.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017
    Article
  18. Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017
    Article
  19. Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Arend M HammingDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Centre Utrecht, Utrecht, The Netherlands.
Marieke J H WermerDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
S Umesh RudrapatnaBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Centre Utrecht, Utrecht, The Netherlands.
Christian LanierDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hine J A van OsDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Walter M van den BerghDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Michel D FerrariDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Annette van der ToornBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Centre Utrecht, Utrecht, The Netherlands.
Arn M J M van den MaagdenbergDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Ann M StoweDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rick M DijkhuizenBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Centre Utrecht, Utrecht, The Netherlands r.m.dijkhuizen@umcutrecht.nl.
Leiden University Medical Center · NLUniversity Medical Center Utrecht · NLThe University of Texas Southwestern Medical Center · USUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spreading depolarizations may contribute to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage, but the effect of spreading depolarizations on brain lesion progression after subarachnoid hemorrhage has not yet been assessed directly. Therefore, we tested the hypothesis that artificially induced spreading depolarizations increase brain tissue damage in a rat model of subarachnoid hemorrhage. Subarachnoid hemorrhage was induced by endovascular puncture of the right internal carotid bifurcation. After one day, brain tissue damage was measured with T2-weighted MRI, followed by application of 1 M KCl (SD group, N = 16) or saline (no-SD group, N = 16) to the right cortex. Cortical laser-Doppler flowmetry was performed to record spreading depolarizations. MRI was repeated on day 3, after which brains were extracted for assessment of subarachnoid hemorrhage severity and histological damage. 5.0 ± 2.7 spreading depolarizations were recorded in the SD group. Subarachnoid hemorrhage severity and mortality were similar between the SD and no-SD groups. Subarachnoid hemorrhage-induced brain lesions expanded between days 1 and 3. This lesion growth was larger in the SD group (241 ± 233 mm(3)) than in the no-SD group (29 ± 54 mm(3)) (p = 0.001). We conclude that induction of spreading depolarizations significantly advances lesion growth after experimental subarachnoid hemorrhage. Our study underscores the pathophysiological consequence of spreading depolarizations in the development of delayed cerebral tissue injury after subarachnoid hemorrhage.

Indexed as

AnimalsBrainBrain IschemiaCortical Spreading DepressionDisease Models, AnimalMagnetic Resonance ImagingMaleRats, WistarSubarachnoid Hemorrhageanimal modelsbrain imagingmagnetic resonancespreading depressionSubarachnoid hemorrhage

Identifiers

PMID26661246
PMCPMC4929702
OpenAlexW2466697787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.