Evidence map›Paper›PMID 26661244›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Altered GABAA receptor density and unaltered blood-brain barrier [11C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis.

Femke E Froklage, Andrey Postnov, Maqsood M Yaqub, Esther Bakker, Ronald Boellaard, N Harry Hendrikse, Emile Fi Comans, Robert C Schuit, Patrick Schober, Demetrios N Velis and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Brain PET imaging usingJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  2. Abnormal Expression of Synaptic and Extrasynaptic GABAInternational journal of molecular sciences · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Femke E FroklageDepartment of Neurology, Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, the Netherlands f.froklage@vumc.nl.
Andrey PostnovDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Maqsood M YaqubDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Esther BakkerDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Ronald BoellaardDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
N Harry HendrikseDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Emile Fi ComansDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Robert C SchuitDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Patrick SchoberDepartment of Anesthesiology, VU University Medical Center, Amsterdam, the Netherlands.
Demetrios N VelisDepartment of Neurology, Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, the Netherlands.
Jack ZwemmerDepartment of Neurology, Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, the Netherlands.
Jan J HeimansDepartment of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
Adriaan A LammertsmaDepartment of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Rob A VoskuylDepartment of Neurology, Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, the Netherlands.
Jaap C ReijneveldDepartment of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
Amsterdam UMC Location VUmc · NLStichting Epilepsie Instellingen Nederland · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies in rodents suggest that flumazenil is a P-glycoprotein substrate at the blood-brain barrier. This study aimed to assess whether [

Indexed as

AdolescentAdultATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierCarbon RadioisotopesDrug ResistanceEpilepsy, Temporal LobeFlumazenilGABA ModulatorsHumansMiddle AgedPositron-Emission TomographyReceptors, GABA-ASclerosisYoung AdultATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesFlumazenilGABA ModulatorsReceptors, GABA-ABlood–brain barrierflumazenilP-glycoproteinpositron emission tomographytemporal lobe epilepsy

Identifiers

PMID26661244
PMCPMC5167109
OpenAlexW2267045208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.