ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
Neurovascular coupling in humans: Physiology, methodological advances and clinical implications.
Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 258 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
258 citing papers in PubMed, 4 syntheses or guidelines pooled it, 471 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Neural Activity Alterations and Their Association With Neurotransmitter and Genetic Profiles in Schizophrenia: Evidence From Clinical Patients and Unaffected Relatives.CNS neuroscience & therapeutics · 2025Pooled it
- A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Associations between neurovascular coupling and cerebral small vessel disease: A systematic review and meta-analysis.European stroke journal · 2023Pooled it
- Trial
- Differential effects of caffeine, acute aerobic exercise, and placebo on mental fatigue.PloS one · 2026Trial
- Acute hypoxia impairs posterior cerebral bioenergetics and memory in man.Experimental physiology · 2023Trial
- The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial.Scientific reports · 2023Trial
- Trial
- The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study.Reproductive sciences (Thousand Oaks, Calif.) · 2021Trial
- Orthostatic hypotension and acute cognitive dysfunction in Parkinson's disease: insights from functional near-infrared spectroscopy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence.Biological psychiatry global open science · 2026Article
- Neurogenic Cerebral Edema: Proposed Mechanism for Vasogenic Cerebral Edema.Neurocritical care · 2026Article
- Article
- Molecular mechanisms of blood-brain barrier dysfunction caused by obesity: pathophysiological understandings and treatment targets.Metabolic brain disease · 2026Review
- Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation.Journal of advanced research · 2026Article
- Assessment of early-phase [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- The cerebral neurovascular coupling and glymphatic circulation dysfunction in children with attention deficit/hyperactivity disorder.BMC psychiatry · 2026Article
- Effect of ketamine intervention on hemodynamic responses in patients with treatment-resistant depression.Scientific reports · 2026Article
- Brain Aging Mediating Heart Imaging-Derived Phenotypes and Mental and Nervous System Disorders.Aging cell · 2026Article
198 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurovascular coupling reflects the close temporal and regional linkage between neural activity and cerebral blood flow. Although providing mechanistic insight, our understanding of neurovascular coupling is largely limited to non-physiologicalex vivopreparations and non-human models using sedatives/anesthetics with confounding cerebrovascular implications. Herein, with particular focus on humans, we review the present mechanistic understanding of neurovascular coupling and highlight current approaches to assess these responses and the application in health and disease. Moreover, we present new guidelines for standardizing the assessment of neurovascular coupling in humans. To improve the reliability of measurement and related interpretation, the utility of new automated software for neurovascular coupling is demonstrated, which provides the capacity for coalescing repetitive trials and time intervals into single contours and extracting numerous metrics (e.g., conductance and pulsatility, critical closing pressure, etc.) according to patterns of interest (e.g., peak/minimum response, time of response, etc.). This versatile software also permits the normalization of neurovascular coupling metrics to dynamic changes in arterial blood gases, potentially influencing the hyperemic response. It is hoped that these guidelines, combined with the newly developed and openly available software, will help to propel the understanding of neurovascular coupling in humans and also lead to improved clinical management of this critical physiological function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.