ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
The effects of hemodynamic lag on functional connectivity and behavior after stroke.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed.
- Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke.Journal of neurochemistry · 2021Trial
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging.Neurophotonics · 2026Article
- Leveraging Task FMRI Data to Extract Resting-State Metrics in Brain Tumor and Healthy Populations.Clinical neuroradiology · 2026Article
- Functional Magnetic Resonance Imaging Signal Typically Viewed as "Noise" Has Clinical Relevance in Psychiatry.Biological psychiatry global open science · 2026Article
- The Cerebrovascular Reactivity Adjusted Fractional Amplitude of Low-Frequency Fluctuations Abnormalities in Middle Cerebral Artery Stenosis and Occlusive Disease.Translational stroke research · 2026Article
- Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain.Fluids and barriers of the CNS · 2026Article
- Dynamic Interactions Between Hemispheres Reveal a Compensatory Pathway for Motor Recovery in Moderate-to-Severe Subcortical Stroke.Journal of stroke · 2026Article
- The Cerebellar Connectome Disruptions in Ischemic Stroke.CNS neuroscience & therapeutics · 2026Article
- Voxelwise degree centrality alterations and cognitive performance in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction.Frontiers in aging neuroscience · 2026Article
- Iterative delay correction improves breath-hold cerebrovascular reactivity mapping in clinical populations.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Timing Is Everything: Temporal Dynamics of BOLD Responses to Naturalistic Features in Movie Watching.bioRxiv : the preprint server for biology · 2025Article
- The effects of sex and age on movie-watching functional connectivity and movie clip classification.Brain structure & function · 2025Article
- Chronic Glymphatic Dysfunction Modulates Domain-Specific Cognitive Recovery After Stroke: A DTI-ALPS Lesion Stratification Study.CNS neuroscience & therapeutics · 2025Article
- Infection with Toxoplasma gondii triggers coagulation at the blood-brain barrier and a reduction in cerebral blood flow.Journal of neuroinflammation · 2025Article
- Evaluating lesion-specific preprocessing pipelines for rs-fMRI in stroke patients: Impact on functional connectivity and behavioral prediction.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Reshaped functional connectivity gradients in acute ischemic stroke.NeuroImage. Clinical · 2025Article
- Structural and functional connectivity of vestibular graviceptive to sensory and motor circuits.Brain communications · 2025Article
- Determinants of brain network resilience after stroke.Brain communications · 2025Article
- Cognitive impairment after intravenous thrombolysis in mild stroke: assessment of cerebral blood flow covariance network.Frontiers in neurology · 2025Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Stroke disrupts the brain's vascular supply, not only within but also outside areas of infarction. We investigated temporal delays (lag) in resting state functional magnetic resonance imaging signals in 130 stroke patients scanned two weeks, three months and 12 months post stroke onset. Thirty controls were scanned twice at an interval of three months. Hemodynamic lag was determined using cross-correlation with the global gray matter signal. Behavioral performance in multiple domains was assessed in all patients. Regional cerebral blood flow and carotid patency were assessed in subsets of the cohort using arterial spin labeling and carotid Doppler ultrasonography. Significant hemodynamic lag was observed in 30% of stroke patients sub-acutely. Approximately 10% of patients showed lag at one-year post-stroke. Hemodynamic lag corresponded to gross aberrancy in functional connectivity measures, performance deficits in multiple domains and local and global perfusion deficits. Correcting for lag partially normalized abnormalities in measured functional connectivity. Yet post-stroke FC-behavior relationships in the motor and attention systems persisted even after hemodynamic delays were corrected. Resting state fMRI can reliably identify areas of hemodynamic delay following stroke. Our data reveal that hemodynamic delay is common sub-acutely, alters functional connectivity, and may be of clinical importance.
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