ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The radiotracer [Annals of nuclear medicine · 2026Review
- Influence of environmental enrichment on rodents' brains: neurochemical and neuroanatomical aspects.Frontiers in veterinary science · 2026Review
- Environmental enrichment improves deficits in hippocampal neuroplasticity and cognition in prenatally aripiprazole-exposed mouse offspring.Translational psychiatry · 2025Article
- Exposure to an enriched environment modulates the synaptic vesicle cycle in a mouse spinal cord injury model.Scientific reports · 2024Article
- Enriched Environment Enhances Sociability Through the Promotion of ESyt1-Related Synaptic Formation in the Medial Prefrontal Cortex.Molecular neurobiology · 2024Article
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Modeling dopamine dysfunction in autism spectrum disorder: From invertebrates to vertebrates.Neuroscience and biobehavioral reviews · 2022Review
- An enriched environment reduces chronic stress-induced visceral pain through modulating microglial activity in the central nucleus of the amygdala.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Role of Organic Cation Transporter 3 and Plasma Membrane Monoamine Transporter in the Rewarding Properties and Locomotor Sensitizing Effects of Amphetamine in Male andFemale Mice.International journal of molecular sciences · 2021Article
- Environmental influences on the pace of brain development.Nature reviews. Neuroscience · 2021Review
- Article
- Dopamine and addiction: what have we learned from 40 years of research.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- PET Measures of D1, D2, and DAT Binding Are Associated With Heightened Tactile Responsivity in Rhesus Macaques: Implications for Sensory Processing Disorder.Frontiers in integrative neuroscience · 2019Article
- An Enriched Environment Ameliorates Oxidative Stress and Olfactory Dysfunction in Parkinson's Disease with α-Synucleinopathy.Cell transplantation · 2018Article
- Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors.Frontiers in synaptic neuroscience · 2018Article
- Environmental Enrichment Upregulates Striatal Synaptic Vesicle-Associated Proteins and Improves Motor Function.Frontiers in neurology · 2018Article
- Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury.Journal of visualized experiments : JoVE · 2017Article
- Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study.Frontiers in aging neuroscience · 2016Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental enrichment (EE) with a complex combination of physical, cognitive and social stimulations enhances synaptic plasticity and behavioral function. However, the mechanism remains to be elucidated in detail. We aimed to investigate dopamine-related synaptic plasticity underlying functional improvement after EE. For this, six-week-old CD-1 mice were randomly allocated to EE or standard conditions for two months. EE significantly enhanced behavioral functions such as rotarod and ladder walking tests. In a [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.