ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing the diagnostic accuracy of CT perfusion: a systematic review.Frontiers in neurology · 2023Pooled it
- Trial
- Does variability in automated perfusion software outputs for acute ischemic stroke matter? Reanalysis of EXTEND perfusion imaging.CNS neuroscience & therapeutics · 2022Trial
- A multicenter randomized controlled trial of endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3).International journal of stroke : official journal of the International Stroke Society · 2017Trial
- Comparison of PMAneo and RAPID in acute ischemic stroke: agreement in CT perfusion analysis and DEFUSE 3 imaging eligibility.Japanese journal of radiology · 2026Article
- Automated CTA-Derived Collateral Grading and Morphologic Metrics for Enhanced Prediction of Poststroke Outcomes.AJNR. American journal of neuroradiology · 2026Article
- Quantitative Cerebrovascular Analysis for Improved Prediction of Post-Stroke Complications.Translational stroke research · 2026Article
- ASPECTS as a surrogate marker of core-perfusion mismatch in late-window large vessel occlusion stroke.European stroke journal · 2026Article
- Influence of slice thickness on computed tomography perfusion-derived ischemic core volume accuracy in acute ischemic stroke.Quantitative imaging in medicine and surgery · 2026Article
- Quantitative Cerebrovascular Analysis for Improved Prediction of Post-Stroke Complications.medRxiv : the preprint server for health sciences · 2026Article
- Evolution of CT perfusion software in stroke imaging: from deconvolution to artificial intelligence.European radiology · 2026Review
- Adjusting input arterial function to improve the accuracy of hypoperfusion assessment in computed tomography perfusion (CTP) for stroke: a preliminary study.Quantitative imaging in medicine and surgery · 2025Article
- Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion.Stroke (Hoboken, N.J.) · 2025Article
- A Comparison of Three Perfusion Algorithms in Patients at Risk of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.Diagnostics (Basel, Switzerland) · 2025Article
- Survey on sampling conditioned brain images and imaging measures with generative models.Biomedical engineering letters · 2025Review
- Hypodensity Beyond the Ischemic Core: Penumbral Changes Detected With Relative Noncontrast Computed Tomography.Stroke · 2025Observational
- A Novel Self-Supervised Learning-Based Method for Dynamic CT Brain Perfusion Imaging.Journal of imaging informatics in medicine · 2025Article
- Noise-induced self-supervised hybrid UNet transformer for ischemic stroke segmentation with limited data annotations.Scientific reports · 2025Article
- Article
- Mismatch Vs No Mismatch in Large Core-A Matter of Definition.Clinical neuroradiology · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Differences in research methodology have hampered the optimization of Computer Tomography Perfusion (CTP) for identification of the ischemic core. We aim to optimize CTP core identification using a novel benchmarking tool. The benchmarking tool consists of an imaging library and a statistical analysis algorithm to evaluate the performance of CTP. The tool was used to optimize and evaluate an in-house developed CTP-software algorithm. Imaging data of 103 acute stroke patients were included in the benchmarking tool. Median time from stroke onset to CT was 185 min (IQR 180-238), and the median time between completion of CT and start of MRI was 36 min (IQR 25-79). Volumetric accuracy of the CTP-ROIs was optimal at an rCBF threshold of <38%; at this threshold, the mean difference was 0.3 ml (SD 19.8 ml), the mean absolute difference was 14.3 (SD 13.7) ml, and CTP was 67% sensitive and 87% specific for identification of DWI positive tissue voxels. The benchmarking tool can play an important role in optimizing CTP software as it provides investigators with a novel method to directly compare the performance of alternative CTP software packages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.