ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches.
Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Parametric imaging of dynamic long-axial-field-of-view PET scans: Technical challenges, statistical insights and clinical applications.Zeitschrift fur medizinische Physik · 2026Review
- Network-based disease fingerprinting with neuroinflammation PET imaging.Journal of neuroinflammation · 2026Article
- TSPO circadian pattern: a test-retest study of [European journal of nuclear medicine and molecular imaging · 2025Article
- Translocator protein (TSPO) positron emission tomography imaging and expression in patients with brain metastases.European journal of nuclear medicine and molecular imaging · 2025Article
- Network-based disease fingerprinting with neuroinflammation PET imaging.Research square · 2025Article
- Use of relative Patlak plot Ki' images as an alternative to standard Patlak plot Ki images in clinical practice.EJNMMI research · 2025Article
- Assessment of image-derived input functions from small vessels for patlak parametric imaging using total-body PET/CT.European journal of nuclear medicine and molecular imaging · 2025Article
- Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [Frontiers in nuclear medicine · 2025Article
- EMATA: a toolbox for the automatic extraction and modeling of arterial inputs for tracer kinetic analysis in [EJNMMI physics · 2024Article
- Exact parameter identification in PET pharmacokinetic modeling using the irreversible two tissue compartment modelPhysics in medicine and biology · 2024Article
- Kinetic analysis of cardiac dynamicHeliyon · 2024Article
- A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging.Frontiers in neuroscience · 2024Article
- Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.European journal of nuclear medicine and molecular imaging · 2023Review
- Supervised clustering for TSPO PET imaging.European journal of nuclear medicine and molecular imaging · 2021Review
- Positron emission tomography in multiple sclerosis - straight to the target.Nature reviews. Neurology · 2021Review
- Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- First-in-human evaluation of [European journal of nuclear medicine and molecular imaging · 2020Article
- Development of a non-radiometric method for measuring the arterial input function of aScientific reports · 2020Article
- Guidelines for the content and format of PET brain data in publications and archives: A consensus paper.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Full kinetic modeling of dynamic PET images requires the measurement of radioligand concentrations in the arterial plasma. The unchanged parent radioligand must, however, be separated from its radiometabolites by chromatographic methods. Thus, only few samples can usually be analyzed and the resulting measurements are often noisy. Therefore, the measurements must be fitted with a mathematical model. This work presents a comprehensive analysis of the different models proposed in the literature to describe the plasma parent fraction (PPf) and of the alternative approaches for radiometabolite correction. Finally, we used a dataset of [(11)C]PBR28 brain PET data as a case study to guide the reader through the PPf model selection process.
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