ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
Time delay processing of hypercapnic fMRI allows quantitative parameterization of cerebrovascular reactivity and blood flow delays.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Microvascular Function and Ambulatory Capacity in Peripheral Artery Disease.Circulation. Cardiovascular interventions · 2025Trial
- Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Leveraging Task FMRI Data to Extract Resting-State Metrics in Brain Tumor and Healthy Populations.Clinical neuroradiology · 2026Article
- Cerebrovascular Reactivity Assessment with Breath-Hold Functional MRI in Patients with Moyamoya Angiopathy: Which Time Period to Analyze?Diagnostics (Basel, Switzerland) · 2026Article
- Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke.bioRxiv : the preprint server for biology · 2026Article
- Iterative delay correction improves breath-hold cerebrovascular reactivity mapping in clinical populations.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- MRI mapping of hemodynamics in the human spinal cord.Scientific reports · 2025Article
- Functional MRI signatures of autonomic physiology in aging.Communications biology · 2025Article
- Measuring cerebrovascular reactivity with breath-hold fMRI in patients with Moyamoya angiopathy: MR perfusion based delay correction significantly improves agreement to [Neuroradiology · 2025Article
- Presenting cerebrovascular reactivity as a determinant of direct and indirect surgical revascularization success in North American patients with moyamoya vasculopathy.Journal of neurosurgery · 2025Article
- Improving delay and strength maps derived from resting-state fMRI using PCA-based denoising and group data from the HCP dataset.Computers in biology and medicine · 2025Article
- Functional MRI Signatures of Autonomic Physiology in Aging.bioRxiv : the preprint server for biology · 2025Article
- The Physiological Component of the BOLD Signal: Impact of Age and Heart Rate Variability Biofeedback Training.bioRxiv : the preprint server for biology · 2025Article
- The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebrovascular reactivity and response times describe recent ischaemic symptomatology in patients with moyamoya.Brain communications · 2025Article
- Quantitative mapping of cerebrovascular reactivity amplitude and delay with breath-hold BOLD fMRI when end-tidal COImaging neuroscience (Cambridge, Mass.) · 2025Article
- Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence.bioRxiv : the preprint server for biology · 2024Article
- COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- CVRmap-a complete cerebrovascular reactivity mapping post-processing BIDS toolbox.Scientific reports · 2024Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Blood oxygenation level-dependent fMRI contrast depends on the volume and oxygenation of blood flowing through the circulatory system. The effects on image intensity depend temporally on the arrival of blood within a voxel, and signal can be monitored during the time course of such blood flow. It has been previously shown that the passage of global endogenous variations in blood volume and oxygenation can be tracked as blood passes through the brain by determining the strength and peak time lag of their cross-correlation with blood oxygenation level-dependent data. By manipulating blood composition using transient hypercarbia and hyperoxia, we can induce much larger oxygenation and volume changes in the blood oxygenation level-dependent signal than result from natural endogenous fluctuations. This technique was used to examine cerebrovascular parameters in healthy subjects (n = 8) and subjects with intracranial stenosis (n = 22), with a subgroup of intracranial stenosis subjects scanned before and after surgical revascularization (n = 6). The halfwidth of cross-correlation lag times in the brain was larger in IC stenosis subjects (21.21 ± 14.22 s) than in healthy control subjects (8.03 ± 3.67), p < 0.001, and was subsequently reduced in regions that co-localized with surgical revascularization. These data show that blood circulatory timing can be measured robustly and longitudinally throughout the brain using simple respiratory challenges.
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