Evidence map›Paper›PMID 26661183›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016

Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.

Evan D McConnell, Helen S Wei, Katherine M Reitz, Hongyi Kang, Takahiro Takano, G Edward Vates, Maiken Nedergaard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Long-acting statin for aneurysmal subarachnoid hemorrhage: A randomized, double-blind, placebo-controlled trial.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Trial
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Capillary responses to functional and pathological activations rely on the capillary states at rest.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  10. Article
  11. Fluid transport in the brain.Physiological reviews · 2022
    Review
  12. Article
  13. The neurovascular extracellular matrix in health and disease.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  14. Article
  15. Hyaluronidase reduced edema after experimental traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Evan D McConnellCenter for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA evan_mcconnell@urmc.rochester.edu.
Helen S WeiCenter for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Katherine M ReitzCenter for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Hongyi KangCenter for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Takahiro TakanoCenter for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA.
G Edward VatesCenter for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Maiken NedergaardCenter for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Neurological Surgery · USUniversity of Rochester Medical Center · US

Funding

Glymphatic function in a transgenic rat model of Alzheimer's diseaseR01AG048769 · NIA · UNIVERSITY OF ROCHESTER · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2014 to 2018
$1.4M
Analgesic actions of adenosine A1 receptor along axonal tracts in chronic painR01AT007945 · NCCIH · UNIVERSITY OF ROCHESTER · PI TAKANO, TAKAHIRO · 2013 to 2017
$1.4M
NCCIH NIH HHS R01 AT007945NIA NIH HHS R01 AG048769
6 · The paper itself

Abstract

Aneurysmal subarachnoid hemorrhage remains one of the more devastating forms of stroke due in large part to delayed cerebral ischemia that appears days to weeks following the initial hemorrhage. Therapies exclusively targeting large caliber arterial vasospasm have fallen short, and thus we asked whether capillary dysfunction contributes to delayed cerebral ischemia after subarachnoid hemorrhage. Using a mouse model of subarachnoid hemorrhage and two-photon microscopy we showed capillary dysfunction unrelated to upstream arterial constriction. Subarachnoid hemorrhage decreased RBC velocity by 30%, decreased capillary pulsatility by 50%, and increased length of non-perfusing capillaries by 15%. This was accompanied by severe brain hypoxia and neuronal loss. Hyaluronidase, an enzyme that alters capillary blood flow by removing the luminal glycocalyx, returned RBC velocity and pulsatility to normal. Hyaluronidase also reversed brain hypoxia and prevented neuron loss typically seen after subarachnoid hemorrhage. Thus, subarachnoid hemorrhage causes specific changes in capillary RBC flow independent of arterial spasm, and hyaluronidase treatment that normalizes capillary blood flow can prevent brain hypoxia and injury after subarachnoid hemorrhage. Prevention or treatment of capillary dysfunction after subarachnoid hemorrhage may reduce the incidence or severity of subarachnoid hemorrhage-induced delayed cerebral ischemia.

Indexed as

AnimalsBrain IschemiaCapillariesCerebrovascular CirculationHyaluronoglucosaminidaseHypoxiaMiceMicrocirculationSubarachnoid HemorrhageHyaluronoglucosaminidaseCapillariescerebral blood flowcerebrovascular diseasesubarachnoid hemorrhagetwo-photon microscopy

Identifiers

PMID26661183
PMCPMC5012515
OpenAlexW2285161824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.