Evidence map›Paper›PMID 26661180›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016

The effects of therapeutic hypothermia on cerebral metabolism in neonates with hypoxic-ischemic encephalopathy: An in vivo 1H-MR spectroscopy study.

Jessica L Wisnowski, Tai-Wei Wu, Aaron J Reitman, Claire McLean, Philippe Friedlich, Douglas Vanderbilt, Eugenia Ho, Marvin D Nelson, Ashok Panigrahy, Stefan Blüml

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 59 citations in OpenAlex.

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  18. Neuroimaging in the term newborn with neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jessica L WisnowskiDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA Brain and Creativity Institute, University of Southern California, Los Angeles, CA, USA Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA Rudi Schulte Research Institute, Santa Barbara, CA, USA jwisnowski@chla.usc.edu.
Tai-Wei WuDepartment of Pediatrics, Division of Neonatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan Department of Pediatrics, Division of Neonatology, Chang Gung University, Taoyuan, Taiwan.
Aaron J ReitmanCenter for Fetal and Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA Department of Pediatrics, Division of Neonatal Medicine, University of Southern California, Los Angeles, CA, USA.
Claire McLeanCenter for Fetal and Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA Department of Pediatrics, Division of Neonatal Medicine, University of Southern California, Los Angeles, CA, USA.
Philippe FriedlichCenter for Fetal and Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA Department of Pediatrics, Division of Neonatal Medicine, University of Southern California, Los Angeles, CA, USA.
Douglas VanderbiltCenter for Fetal and Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA Department of Pediatrics, Developmental-Behavioral Pediatrics, University of Southern California, Los Angeles, CA, USA.
Eugenia HoCenter for Fetal and Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA Department of Pediatrics, Division of Child Neurology, University of Southern California, Los Angeles, CA, USA.
Marvin D NelsonDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Ashok PanigrahyDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA Brain and Creativity Institute, University of Southern California, Los Angeles, CA, USA Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
Stefan BlümlDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA Rudi Schulte Research Institute, Santa Barbara, CA, USA.
University of Southern California · USChildren's Hospital of Los Angeles · USChang Gung University · TWChildren's Hospital of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic hypothermia has emerged as the first empirically supported therapy for neuroprotection in neonates with hypoxic-ischemic encephalopathy (HIE). We used magnetic resonance spectroscopy ((1)H-MRS) to characterize the effects of hypothermia on energy metabolites, neurotransmitters, and antioxidants. Thirty-one neonates with HIE were studied during hypothermia and after rewarming. Metabolite concentrations (mmol/kg) were determined from the thalamus, basal ganglia, cortical grey matter, and cerebral white matter. In the thalamus, phosphocreatine concentrations were increased by 20% during hypothermia when compared to after rewarming (3.49 ± 0.88 vs. 2.90 ± 0.65, p < 0.001) while free creatine concentrations were reduced to a similar degree (3.00 ± 0.50 vs. 3.74 ± 0.85, p < 0.001). Glutamate (5.33 ± 0.82 vs. 6.32 ± 1.12, p < 0.001), aspartate (3.39 ± 0.66 vs. 3.87 ± 1.19, p < 0.05), and GABA (0.92 ± 0.36 vs. 1.19 ± 0.41, p < 0.05) were also reduced, while taurine (1.39 ± 0.52 vs. 0.79 ± 0.61, p < 0.001) and glutathione (2.23 ± 0.41 vs. 2.09 ± 0.33, p < 0.05) were increased. Similar patterns were observed in other brain regions. These findings support that hypothermia improves energy homeostasis by decreasing the availability of excitatory neurotransmitters, and thereby, cellular energy demand.

Indexed as

Hypothermia, InducedAntioxidantsBrainHomeostasisHumansHypoxia-Ischemia, BrainInfant, NewbornMagnetic Resonance ImagingNeurotransmitter AgentsRewarmingAntioxidantsNeurotransmitter AgentsEnergy metabolismglutamatehypothermianeonatal ischemianeuroprotectionneurotransmitters

Identifiers

PMID26661180
PMCPMC4908621
OpenAlexW2258561797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.