Evidence map›Paper›PMID 26660727›Full record

ArticleInternational orthopaedics2016

Multicentric epidemiologic study on six thousand three hundred and ninety five cases of femoral head osteonecrosis in China.

Liqiang Cui, Qianyu Zhuang, Jin Lin, Jin Jin, Ke Zhang, Li Cao, Jianhao Lin, Shigui Yan, Wanshou Guo, Wei He and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  5. BioMed research international · 2019
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  7. [Mechanisms of RNA-binding protein phase separation in steroid-associated necrosis of the femoral head].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liqiang CuiDepartment of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing, 100730, China.
Qianyu ZhuangDepartment of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing, 100730, China.
Jin LinDepartment of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing, 100730, China.
Jin JinDepartment of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing, 100730, China.
Ke ZhangDepartment of Orthopaedics, Peking University Third Hospital, North Garden Rd No. 49, Haidian District, Beijing, 100191, China.
Li CaoDepartment of Orthopaedics, The First Teaching Hospital of Xinjiang Medical University, South Liyushan street No. 137, Wulumuqi, Xinjiang Province, 830054, China.
Jianhao LinDepartment of Orthopaedics, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China.
Shigui YanDepartment of Orthopaedics, The First Affiliated Hospital of Zhejiang University, Qingchun street No. 79, Hangzhou, Zhejiang Province, 310003, China.
Wanshou GuoDepartment of Orthopaedics, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Hepingli, Beijing, 100029, China.
Wei HeDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, No. 16 Airport Street, Guangzhou, 510405, China.
Fuxing PeiDepartment of Orthopaedics, West China Hospital, Sichuan University, No. 37, Guoxue Street, Wuhou district, Chengdu, Sichuan, 610041, China.
Yixin ZhouDepartment of Orthopaedics, Beijing Jishuitan Hospital, No. 31 Eastern Xinjiekou Street, Xicheng district, Beijing, 100035, China.
Xisheng WengDepartment of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing, 100730, China. xsh_weng@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOsteonecrosis of femoral head (ONFH) is a common joint disease with high morbidity in mainland China. We performed a retrospective case investigation based on the widest range of patients ever to reveal the demographic and clinical characteristics of ONFH in mainland China.

methodsWe collected data from hospitalized patients of nine large tertiary hospitals in China, focusing on the aetiology of ONFH. Medical records and self-design questionnaires were used to collect data. We determined the patients' aetiology according to established guidelines and categorized patients into different subgroups. We further analysed the underlying illness of the steroid-induced osteonecrosis of femoral head.

resultsA total of 6,395 patients with complete medical records were included in the study. The age (mean ± SD) of the patients was 46.45 ± 13.80 years. Males dominate with 70.1 % of all ONFH patients. In all the ONFH patients, 24.1 % are steroid induced, 30.7 % are alcoholic, 16.4 % are traumatic and 28.8 % are idiopathic. Among steroid-induced osteonecrosis of femoral head patients, 546 patients have autoimmune disorder (46.63 %), which is the most common underling illness, among these, the most common disease is systemic lupus erythematosus (SLE).

conclusionsThe most common age when ONFH occurs is between 40 and 50 years old. Male patients developed ONFH 3.4 years earlier than female patients. The number of the male patients is greater than the female, reaching the overall gender proportion of 7:3. Autoimmune disease is the primary cause of steroid-induced ONFH, among which SLE is the most common disease.

Indexed as

AdultAgedAge DistributionChinaCross-Sectional StudiesFemaleFemur HeadFemur Head NecrosisHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSex DistributionSurveys and QuestionnairesYoung AdultEtiologyOsteonecrosis of femoral headRisk factor

Identifiers

PMID26660727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.