ArticlePhysiological reports2015
Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- The hidden cost of antibiotics: microbial dysbiosis-induced SCFA imbalance and its underlying mechanisms.Frontiers in immunology · 2026Review
- Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges.Advanced healthcare materials · 2025Review
- The maternal microbiome promotes placental development in mice.Science advances · 2023Article
- Reduced intestinal butyrate availability is associated with the vascular remodeling in resistance arteries of hypertensive rats.Frontiers in physiology · 2022Article
- Suppression of local type I interferon by gut microbiota-derived butyrate impairs antitumor effects of ionizing radiation.The Journal of experimental medicine · 2021Article
- Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.Journal of the American Heart Association · 2020Article
- Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty.Journal of vascular surgery · 2020Article
- Review
- Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3K/Akt Signaling Network.International journal of molecular sciences · 2019Article
- Antibiotic Treatment Protocols and Germ-Free Mouse Models in Vascular Research.Frontiers in immunology · 2019Review
- The Role of the Microbiota in the Diabetic Peripheral Artery Disease.Mediators of inflammation · 2019Review
- Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids.Mucosal immunology · 2018Article
- Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.PloS one · 2018Article
- Corrigendum.Physiological reports · 2016Article
- The Future of Vascular Biology and Medicine.Circulation · 2016Review
- Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions.Genome medicine · 2016Review
- Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury.Physiological reports · 2015Article
Corrections and comments
- Erratum issuedCorrigendum.2016
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Gut microbial metabolites are increasingly recognized as determinants of health and disease. However, whether host -: microbe crosstalk influences peripheral arteries is not understood. Neointimal hyperplasia, a proliferative and inflammatory response to arterial injury, frequently limits the long-term benefits of cardiovascular interventions such as angioplasty, stenting, and bypass surgery. Our goal is to assess the effect of butyrate, one of the principal short chain fatty acids produced by microbial fermentation of dietary fiber, on neointimal hyperplasia development after angioplasty. Treatment of male Lewis Inbred rats with oral vancomycin for 4 weeks changed the composition of gut microbes as assessed by 16S rRNA-based taxonomic profiling and decreased the concentration of circulating butyrate by 69%. In addition, rats treated with oral vancomycin had exacerbated neointimal hyperplasia development after carotid angioplasty. Oral supplementation of butyrate reversed these changes. Butyrate also inhibited vascular smooth muscle cell proliferation, migration, and cell cycle progression in a dose-dependent manner in vitro. Our results suggest for the first time that gut microbial composition is associated with the severity of arterial remodeling after injury, potentially through an inhibitory effect of butyrate on VSMC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.