ArticleEJNMMI research2015
Correlation between apoptosis and left ventricular remodeling in subacute phase of myocardial ischemia and reperfusion.
Article in EJNMMI research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being.Nutrition & metabolism · 2024Review
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Metabolic Imaging in Cardio-oncology.Journal of cardiovascular translational research · 2020Review
- Serial examination of cardiac function and perfusion in growing rats using SPECT/CT for small animals.Scientific reports · 2020Article
- The bifunctional SDF-1-AnxA5 fusion protein protects cardiac function after myocardial infarction.Journal of cellular and molecular medicine · 2019Article
- Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction.Molecular imaging and biology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate whether an apoptotic process demonstrated by (99m)Tc-annexin-V ((99m)Tc-AV) uptake correlates with left ventricular remodeling (LVR) after myocardial infarction, we assessed (99m)Tc-AV uptake in rat model of myocardial ischemia and reperfusion.
methodsThe left coronary artery (LCA) of 15 rats was occluded for 20 to 30 min, followed by reperfusion. After 2 weeks, (99m)Tc-AV was injected, and then 1 h later, (201)Tl was injected after reocclusion of the LCA. Dual-tracer autoradiography was performed to assess (99m)Tc-AV uptake and the area at risk (AAR) by (201)Tl defect. (99m)Tc-AV uptake ratio was calculated by dividing the count density of the AAR by that of the normally perfused area. In short-axis LV slices, LV cavity dilation index (DI) was calculated by dividing the area of LV cavity by that of the whole LV area. LV wall-thinning ratio (WTR) was calculated by dividing the LV wall thickness in the AAR by that of the normally perfused area.
resultsSignificant (99m)Tc-AV uptake in the AAR was observed in 10 rats. DI was significantly higher in rats with positive (99m)Tc-AV uptake than in rats without uptake. WTR was smaller in rats with positive (99m)Tc-AV uptake than in rats without uptake.
conclusionsThe data suggest (99m)Tc-AV uptake in injured myocardium might correlate with LVR at 2 weeks after myocardial ischemia and reperfusion.
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