Evidence map›Paper›PMID 26660497›Full record

ArticleMolecular neurobiology2016

Ketamine Inhibits ATP-Evoked Exocytotic Release of Brain-Derived Neurotrophic Factor from Vesicles in Cultured Rat Astrocytes.

Matjaž Stenovec, Eva Lasič, Mićo Božić, Saša Trkov Bobnar, Randy F Stout, Vladimir Grubišić, Vladimir Parpura, Robert Zorec

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

  1. Magnetoencephalographic Correlates of Suicidal Ideation in Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020
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  2. Review
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  11. Astrocyte regulation of synaptic signaling in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Exocytosis in Astrocytes.Biomolecules · 2021
    Review
  16. Review
  17. Review
  18. A Brain-Centric Model of Suicidal Behavior.The American journal of psychiatry · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Matjaž StenovecCelica Biomedical, Tehnološki park 24, 1000, Ljubljana, Slovenia.
Eva LasičLaboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia.
Mićo BožićLaboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia.
Saša Trkov BobnarCelica Biomedical, Tehnološki park 24, 1000, Ljubljana, Slovenia.
Randy F StoutDepartment of Neurobiology, Civitan International Research Center and Center for Glial Biology in Medicine, Evelyn F. McKnight Brain Institute, Atomic Force Microscopy and Nanotechnology Laboratories, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 429, Birmingham, AL, 35294, USA.
Vladimir GrubišićDepartment of Neurobiology, Civitan International Research Center and Center for Glial Biology in Medicine, Evelyn F. McKnight Brain Institute, Atomic Force Microscopy and Nanotechnology Laboratories, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 429, Birmingham, AL, 35294, USA.
Vladimir ParpuraDepartment of Neurobiology, Civitan International Research Center and Center for Glial Biology in Medicine, Evelyn F. McKnight Brain Institute, Atomic Force Microscopy and Nanotechnology Laboratories, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 429, Birmingham, AL, 35294, USA.
Robert ZorecCelica Biomedical, Tehnološki park 24, 1000, Ljubljana, Slovenia. robert.zorec@mf.uni-lj.si.
University of Ljubljana · SICelica (Slovenia) · SIUniversity of Alabama at Birmingham · USCivitan International · US

Funding

The Role of Astroglia in the Enteric Nervous System and Gut FunctionR21HD078678 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PARPURA, VLADIMIR · 2014 to 2015
$400k
NICHD NIH HHS R21 HD078678
6 · The paper itself

Abstract

In the brain, astrocytes signal to neighboring cells via regulated exocytotic release of gliosignaling molecules, such as brain-derived neurotrophic factor (BDNF). Recent studies uncovered a role of ketamine, an anesthetic and antidepressant, in the regulation of BDNF expression and in the disruption of astrocytic Ca

Indexed as

Adenosine TriphosphateAnimalsAstrocytesBiomarkersBrain-Derived Neurotrophic FactorCalciumCalcium SignalingCells, CulturedCytoplasmic VesiclesExocytosisHydrogen-Ion ConcentrationKetamineMembrane FusionPurinesRats, WistarSNARE ProteinsAdenosine TriphosphateBiomarkersBrain-Derived Neurotrophic FactorCalciumKetaminePurinesSNARE ProteinsAstrogliaBrain-derived neurotrophic factorCa2+ signalingFusion poreKetamineRegulated exocytosis

Identifiers

PMID26660497
OpenAlexW2218872267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.