Evidence map›Paper›PMID 26660464›Full record

ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2016

Choice of models for QTL mapping with multiple families and design of the training set for prediction of Fusarium resistance traits in maize.

Sen Han, H Friedrich Utz, Wenxin Liu, Tobias A Schrag, Michael Stange, Tobias Würschum, Thomas Miedaner, Eva Bauer, Chris-Carolin Schön, Albrecht E Melchinger

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Genomic loci associated with Fusarium stalk rot resistance and related agronomic traits in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Article
  3. Article
  4. Genome-wide association study and molecular marker development for susceptibility to Gibberella ear rot in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Intercontinental trials reveal stable QTL for Northern corn leaf blight resistance in Europe and in Brazil.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021
    Article
  12. Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sen HanInstitute of Plant Breeding, Seed Science and Population Genetics (350a), University of Hohenheim, 70593, Stuttgart, Germany.
H Friedrich UtzInstitute of Plant Breeding, Seed Science and Population Genetics (350a), University of Hohenheim, 70593, Stuttgart, Germany.
Wenxin LiuCrop Genetics and Breeding Department, China Agricultural University, Beijing, 100193, China.
Tobias A SchragInstitute of Plant Breeding, Seed Science and Population Genetics (350a), University of Hohenheim, 70593, Stuttgart, Germany.
Michael StangeInstitute of Plant Breeding, Seed Science and Population Genetics (350a), University of Hohenheim, 70593, Stuttgart, Germany.
Tobias WürschumState Plant Breeding Institute (720), University of Hohenheim, 70593, Stuttgart, Germany.
Thomas MiedanerState Plant Breeding Institute (720), University of Hohenheim, 70593, Stuttgart, Germany.
Eva BauerDepartment of Plant Breeding, Center of Life and Food Sciences Weihenstephan, Technische Universität München, 85350, Freising, Germany.
Chris-Carolin SchönDepartment of Plant Breeding, Center of Life and Food Sciences Weihenstephan, Technische Universität München, 85350, Freising, Germany.
Albrecht E MelchingerInstitute of Plant Breeding, Seed Science and Population Genetics (350a), University of Hohenheim, 70593, Stuttgart, Germany. melchinger@uni-hohenheim.de.
University of Hohenheim · DETechnical University of Munich · DEChina Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key messageQTL analysis for Fusarium resistance traits with multiple connected families detected more QTL than single-family analysis. Prediction accuracy was tightly associated with the kinship of the validation and training set. ABSTRACT: QTL mapping has recently shifted from analysis of single families to multiple, connected families and several biometric models have been suggested. Using a high-density consensus map with 2472 marker loci, we performed QTL mapping with five connected bi-parental families with 639 doubled-haploid (DH) lines in maize for ear rot resistance and analyzed traits DON, Gibberella ear rot severity (GER), and days to silking (DS). Five biometric models differing in the assumption about the number and effects of alleles at QTL were compared. Model 2 to 5 performing joint analyses across all families and using linkage and/or linkage disequilibrium (LD) information identified all and even further QTL than Model 1 (single-family analyses) and generally explained a higher proportion pG of the genotypic variance for all three traits. QTL for DON and GER were mostly family specific, but several QTL for DS occurred in multiple families. Many QTL displayed large additive effects and most alleles increasing resistance originated from a resistant parent. Interactions between detected QTL and genetic background (family) occurred rarely and were comparatively small. Detailed analysis of three fully connected families yielded higher pG values for Model 3 or 4 than for Model 2 and 5, irrespective of the size NTS of the training set (TS). In conclusion, Model 3 and 4 can be recommended for QTL-based prediction with larger families. Including a sufficiently large number of full sibs in the TS helped to increase QTL-based prediction accuracy (rVS) for various scenarios differing in the composition of the TS.

Indexed as

Models, GeneticQuantitative Trait LociAllelesChromosome MappingCrosses, GeneticDisease ResistanceEpistasis, GeneticFusariumMicrosatellite RepeatsPhenotypePlant DiseasesPolymorphism, Single NucleotideZea mays

Identifiers

PMID26660464
OpenAlexW2193161783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.