ArticlePsychopharmacology2016
Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt.
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What can case-control comparisons of neural drug cue reactivity tell us about addiction? A neuroimaging meta-analysis.Translational psychiatry · 2026Pooled it
- Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers.Journal of abnormal psychology · 2018Trial
- Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers: A Randomized Trial.JAMA psychiatry · 2017Trial
- Positive Emotion Regulation in Addiction: A New Frontier for Recovery Science.Current addiction reports · 2026Review
- Positive face BOLD response and task-dependent ventral striatal functional connectivity during Go/No-go task among abstinent cannabis-using adolescents and young adults.Frontiers in adolescent medicine · 2026Article
- From Pellets to Prizes: Preclinical and Clinical Perspectives on Contingency Management for the Treatment of Substance Use Disorder.Substance abuse and rehabilitation · 2026Review
- Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Testing the efficacy of real-time fMRI neurofeedback for training people who smoke daily to upregulate neural responses to nondrug rewards.Cognitive, affective & behavioral neuroscience · 2023Article
- Overnight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Precision Preventive Medicine of Relapse in Smoking Cessation: Can MRI Inform the Search of Intermediate Phenotypes?Biology · 2021Review
- Associations Between Smoking Abstinence, Inhibitory Control, and Smoking Behavior: An fMRI Study.Frontiers in psychiatry · 2021Article
- Effects of environmental tobacco smoke exposure on brain functioning in never-smoking adolescents.Brain and behavior · 2020Article
- Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder.Science advances · 2019Article
- Using Neuroscience to Inform Tobacco Control Policy.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Review
- The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Brain Gray Matter Volume and Functional Connectivity Are Associated With Smoking Cessation Outcomes.Frontiers in human neuroscience · 2019Article
- Social influence of e-cigarette smoking prevalence on smoking behaviours among high-school teenagers: Microsimulation experiments.PloS one · 2019Article
- Combining ecological momentary assessment with objective, ambulatory measures of behavior and physiology in substance-use research.Addictive behaviors · 2018Review
- Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods.Developmental cognitive neuroscience · 2018Review
- Functional Neurocircuits and Neuroimaging Biomarkers of Tobacco Use Disorder.Trends in molecular medicine · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
rationaleTobacco smoking is associated with dysregulated reward processing within the striatum, characterized by hypersensitivity to smoking rewards and hyposensitivity to non-smoking rewards. This bias toward smoking reward at the expense of alternative rewards is further exacerbated by deprivation from smoking, which may contribute to difficulty maintaining abstinence during a quit attempt.
objectiveWe examined whether abstinence-induced changes in striatal processing of rewards predicted lapse likelihood during a quit attempt supported by contingency management (CM), in which abstinence from smoking was reinforced with money.
methodsThirty-six non-treatment-seeking smokers participated in two functional MRI (fMRI) sessions, one following 24-h abstinence and one following smoking as usual. During each scan, participants completed a rewarded guessing task designed to elicit striatal activation in which they could earn smoking and monetary rewards delivered after the scan. Participants then engaged in a 3-week CM-supported quit attempt.
resultsAs previously reported, 24-h abstinence was associated with increased striatal activation in anticipation of smoking reward and decreased activation in anticipation of monetary reward. Individuals exhibiting greater decrements in right striatal activation to monetary reward during abstinence (controlling for activation during non-abstinence) were more likely to lapse during CM (p < 0.025), even when controlling for other predictors of lapse outcome (e.g., craving); no association was seen for smoking reward.
conclusionsThese results are consistent with a growing number of studies indicating the specific importance of disrupted striatal processing of non-drug reward in nicotine dependence and highlight the importance of individual differences in abstinence-induced deficits in striatal function for smoking cessation.
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