ArticleMolecular neurobiology2016
Postnatal Stress Induced by Injection with Valproate Leads to Developing Emotional Disorders Along with Molecular and Cellular Changes in the Hippocampus and Amygdala.
Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Induction of cerebellar cortical neurogenesis immediately following valproic acid exposure in ferret kits.Frontiers in neuroscience · 2023Article
- Neurogenesis of Subventricular Zone Progenitors in the Premature Cortex of Ferrets Facilitated by Neonatal Valproic Acid Exposure.International journal of molecular sciences · 2022Article
- Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders.Translational psychiatry · 2021Review
- The Proliferation of Dentate Gyrus Progenitors in the Ferret Hippocampus by Neonatal Exposure to Valproic Acid.Frontiers in neuroscience · 2021Article
- Long-term effects of stress early in life on microRNA-30a and its network: Preventive effects of lurasidone and potential implications for depression vulnerability.Neurobiology of stress · 2020Article
- Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline.Translational psychiatry · 2020Article
- Intermittent peripheral exposure to lipopolysaccharide induces exploratory behavior in mice and regulates brain glial activity in obese mice.Journal of neuroinflammation · 2020Article
- Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development.Journal of clinical medicine · 2020Review
- Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats.Journal of translational medicine · 2019Article
- Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors.Oncogene · 2019Article
- Psychoactive drug exposure during breastfeeding: a critical need for preclinical behavioral testing.Psychopharmacology · 2018Review
- Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system.Oncotarget · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress derived from an adverse environment during brain development could contribute to psychiatric disorders. To study the influence of stress occurring at birth on behavior development in human, we performed an intraperitoneal injection (i.p.) of valproic acid (VPA; 200 mg/kg), a histone deacetylation inhibitor (HDACi), into male rat pups at the age of postnatal day 7 (P7) that is equivalent to an infant at 36-40 weeks gestation. Our results showed that neuronal differentiation genes, doublecortin (DCX) and NeuroD1, were downregulated in the hippocampus at 24 h post VPA injection. In addition, the cell proliferation was increased in the dentate gyrus and amygdala of rats receiving VPA injection. DCX
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.