ReviewMolecular neurobiology2016
SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.
Review in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Function of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis.Scientific reports · 2022Article
- Transition between synaptic branch formation and synaptogenesis is regulated by the lin-4 microRNA.Developmental biology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The establishment of neuronal connectivity requires precise orchestration of multiple developmental steps, including axon specification, axon guidance, selection of synaptic target sites, and development of synaptic specializations. Although these are separate developmental steps, evidence indicates that some of the signaling molecules that regulate these steps are shared. In this review, we focus on SYD-1, a RhoGAP-like protein that has been implicated in each step of axonal development. We discuss interactions between SYD-1, UNC-40(DCC) and RhoGTPases and highlight both similarities and differences in how SYD-1 functions to regulate the different steps of axonal development. These observations reveal an example of how a signaling protein can be repurposed across sequential developmental steps.
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Registered trials
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