Evidence map›Paper›PMID 26660092›Full record

ArticleHerz2016

Association between NAD(P)H oxidase p22phox gene variants and acute myocardial infarction in a Han Chinese population.

H Xu, S Ma, F-Y Tang, Y Chen, H Zhou, M Chen, B Wang, X Liu, X Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Herz, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

H XuDepartment of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China.
S MaDepartment of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China.
F-Y TangDepartment of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
Y ChenDepartment of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China.
H ZhouDepartment of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
M ChenDepartment of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
B WangDepartment of Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
X LiuDepartment of Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
X XieDepartment of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China. xie_xiongwei@163.com.
Nanjing Medical University · CNHuaian First People’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the association between five selected single-nucleotide polymorphisms (rs12933505, rs3180279, rs3794264, rs4673, rs1049255) in the NAD(P)H p22phox gene and acute myocardial infarction (AMI) as well as severity of coronary artery stenosis in a Han Chinese population. PATIENTS AND

methodsA total of 168 patients with AMI and 138 healthy controls were recruited. The TaqMan allelic discrimination assay was used to genotype five single-nucleotide polymorphisms.

resultsThe frequency of the rs1049255 G allele was significantly lower in patients with AMI than in controls (p = 0.022). Compared with subjects with an AA genotype, subjects with a GG or AG genotype had a lower risk of AMI [multivariate-adjusted odds ratio (OR), 0.53; 95 % CI, 0.29-0.95; p = 0.031). Subjects with the GG and AG genotypes of rs1049255 showed a decreased susceptibility for triple-vessel disease (TVD) as compared with controls (multivariate-adjusted OR, 0.43; 95 % CI, 0.19-0.98; p = 0.042). Multiple logistic regression analysis revealed that the rs1049255G variant was an independent protective factor for AMI/TVD.

conclusionThe results suggest there is an association between the p22phox rs1049255 polymorphism with the prevalence of AMI and the severity of coronary artery stenosis in the Han Chinese population.

Indexed as

Age DistributionBiomarkersChinaCoronary StenosisFemaleGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseGenetic VariationHumansIncidenceMaleMiddle AgedNADPH OxidasesPolymorphism, Single NucleotideReproducibility of ResultsBiomarkersCYBA protein, humanGenetic MarkersNADPH OxidasesCoronary artery diseaseGene polymorphismMyocardial infarctionNAD(P)H oxidasep22phox gene

Identifiers

PMID26660092
OpenAlexW2202431146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.