ArticleNaunyn-Schmiedeberg's archives of pharmacology2016
Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Exploring the Connection Between BDNF/TrkB and AC/cAMP/PKA/CREB Signaling Pathways: Potential for Neuroprotection and Therapeutic Targets for Neurological Disorders.Molecular neurobiology · 2025Review
- Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.Physiological reviews · 2022Review
- International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.Pharmacological reviews · 2017Review
- Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.Journal of hepatology · 2017Article
- A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer.Current opinion in pharmacology · 2016Review
- Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model.Cell death & disease · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane-bound adenylyl cyclases constitute an interesting therapeutic target for various diseases that affect a large number of patients including asthma or congestive heart failure. Many inhibitors of adenylyl cyclases are competitive inhibitors at the ATP binding site and may, therefore, also interact with one or several of numerous ATP-binding proteins other than adenylyl cyclases. Several such inhibitors also show structural similarity to adenosine receptor ligands, providing a risk for side effects mediated by an unwanted interaction with these receptors. We have investigated a potential specific binding of four representative adenylyl cyclase inhibitors and found binding with pharmacologically relevant affinity to A1 and A2A receptors for NKY80 (2-amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone) and SQ22,536 (9-(tetrahydro-2-furanyl)-9H-purin-6-amine). These results underscore the importance to consider potential side effects mediated via adenosine receptors in the development of potent and specific inhibitors of adenylyl cyclases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.