Evidence map›Paper›PMID 26659841›Full record

ReviewCurrent neurology and neuroscience reports2016

Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus.

Oscar H Del Brutto, Jerome Engel, Dawn S Eliashiv, Hector H García

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 79 citations in OpenAlex.

  1. Volumetric MRI study of the brain in patients with neurocysticercosis and mesial temporal lobe epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026
    Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Human Neurocysticercosis: An Overview.Pathogens (Basel, Switzerland) · 2022
    Review
  10. Epileptogenesis in Common Parasitic Infections.Current neurology and neuroscience reports · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Axonal swelling and spheroids in Taenia solium neurocysticercosis.Brain pathology (Zurich, Switzerland) · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Oscar H Del BruttoSchool of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador. oscardelbrutto@hotmail.com.
Jerome EngelDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Dawn S EliashivDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Hector H GarcíaCenter for Global Health, Tumbes and the Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru.
University of California, Los Angeles · USUniversidad de Especialidades Espíritu Santo · ECUniversidad Peruana Cayetano Heredia · PE

Funding

IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR37NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE · 2004 to 2010
$3.2M
NINDS NIH HHS R37 NS033310Wellcome Trust 091077
6 · The paper itself

Abstract

Neurocysticercosis (NCC) is the most common helminthic infection of the nervous system and a frequent cause of reactive seizures and epilepsy worldwide. In many cases, multiple episodes of focal seizures related to an identifiable parenchymal brain cyst (and likely attributable to local damage) continue for years after the cyst resolves. However, cases where seizure semiology, interictal EEG abnormalities, and parasites location do not correlate raise concerns about the causal relationship between NCC and either reactive seizures or epilepsy, as well as the epileptogenic potential of parasites. Neurosurgical series of patients with intractable epilepsy and cross-sectional population-based studies have shown a robust association between NCC and hippocampal sclerosis (HS), which might contribute to the above-referred inconsistencies. Current information does not allow to define whether in patients with NCC, HS could result from recurrent seizure activity from a local or distant focus or from chronic recurrent inflammation. In either case, HS may become the pathological substrate of subsequent mesial temporal lobe epilepsy (MTLE). Longitudinal clinical- and population-based cohort studies are needed to evaluate the causal relationship between NCC and HS and to characterize this association with the occurrence of MTLE. If a cause-and-effect relationship between NCC and HS is demonstrated, NCC patients could be assessed to examine neuronal mechanisms of hippocampal epileptogenesis in comparison with animal models, to identify biomarkers of hippocampal epileptogenesis, and to develop novel interventions to prevent epilepsy in NCC and perhaps in other forms of acquired epilepsy.

Indexed as

HippocampusAnimalsEpilepsyHumansNeurocysticercosisSclerosisSeizuresCysticercosisEpilepsyHippocampal sclerosisHippocampusNeurocysticercosisSeizures

Identifiers

PMID26659841
PMCPMC5633082
OpenAlexW2258814098

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.