Evidence map›Paper›PMID 26659832›Full record

ArticleBehavior genetics2016

Stability of Genetic and Environmental Contributions to Anxiety Symptoms in Older Adulthood.

Andrew J Petkus, Margaret Gatz, Chandra A Reynolds, William S Kremen, Julie Loebach Wetherell

Abstract read
In one paragraph

Article in Behavior genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genetic and Environmental Associations Among Executive Functions, Trait Anxiety, and Depression Symptoms in Middle Age.Clinical psychological science : a journal of the Association for Psychological Science · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew J PetkusDepartment of Psychology, University of Southern California, 3620 South McClintock Ave., SGM 522, Los Angeles, CA, 90089-1061, USA. petkus@usc.edu.
Margaret GatzDepartment of Psychology, University of Southern California, 3620 South McClintock Ave., SGM 522, Los Angeles, CA, 90089-1061, USA.
Chandra A ReynoldsDepartment of Psychology, University of California, Riverside, Riverside, CA, 92521, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, San Diego, CA, 92093-0603, USA.
Julie Loebach WetherellDepartment of Psychiatry, University of California, San Diego, San Diego, CA, 92093-0603, USA.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
Anxiety and Cognition in Swedish Twins: Genetic and Environmental InfluencesF31AG042218 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETKUS, ANDREW JOHN · 2012 to 2013
$49k
NIA NIH HHS F31 AG042218NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595
6 · The paper itself

Abstract

Anxiety symptoms are common in later life and are associated with diverse adverse health outcomes. Little is known about how genetic and environmental influences on anxiety symptoms might vary across older adulthood. The purpose of this study was to explore change and stability of contributions to anxiety symptoms across older adulthood. We examined data from the Swedish Adoption/Twin Study of Aging (SATSA). Between the years 1984 and 2010, 2021 participants (including 753 complete twin pairs) completed up to seven assessments containing two measures of anxiety symptoms. Longitudinal genetic simplex models were fit to examine the stability and change in genetic and environmental influences. Amplification of genetic factors at ages 75-80 suggests tentative new genetic contributions to anxiety symptoms. These findings suggest that the heritability of anxiety symptoms may increase later in life. Physiological factors associated with aging are discussed as potential factors explaining this increase.

Indexed as

Gene-Environment InteractionAgedAged, 80 and overAge DistributionAnxietyConfidence IntervalsFemaleHumansMaleMiddle AgedModels, StatisticalPersonality InventoryTwins, DizygoticTwins, MonozygoticAnxietyGeneticsLongitudinalOlder adults

Identifiers

PMID26659832
PMCPMC4887343

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.