Evidence map›Paper›PMID 26659828›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2016

Relearning to See in Cortical Blindness.

Michael D Melnick, Duje Tadin, Krystel R Huxlin

Erratum issued Registry-linked trialAbstract readReview
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05085210 (Visual Restoration of Losses Caused by Cortical Damage), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05085210 narecruitingnot on this mapstarted 2022, after this paper: background citation

Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2022 to 2026Enrolled24ConditionsVisual Field Defect, Peripheral, Stroke, Visual Impairment, HemianopsiaArmstranscranial random noise stimulation (tRNS), Computer Based Visual Training, Sham stimulation, Virtual Reality Based Visual Training
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Boosting Learning Efficacy with Noninvasive Brain Stimulation in Intact and Brain-Damaged Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Trial
  5. Exogenous Spatial Attention Helps Overcome Spatial Specificity of Visual Learning in the Blind Field After V1 Damage.Journal of cognitive enhancement : towards the integration of theory and practice · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022
    Article
  14. Article
  15. Delayed-onset hypoxic cortical blindness: coming back from the abyss.Documenta ophthalmologica. Advances in ophthalmology · 2022
    Article
  16. Neural Mechanisms of Visual Field Recovery after Perceptual Training in Cortical Blindness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Michael D MelnickDepartment of Brain & Cognitive Sciences, University of Rochester, Rochester, NY, USA mmelnick@mail.cvs.rochester.edu.
Duje TadinDepartment of Brain & Cognitive Sciences, University of Rochester, Rochester, NY, USA The Flaum Eye Institute, University of Rochester, Rochester, NY, USA The Center for Visual Science, University of Rochester, Rochester, NY, USA.
Krystel R HuxlinDepartment of Brain & Cognitive Sciences, University of Rochester, Rochester, NY, USA The Flaum Eye Institute, University of Rochester, Rochester, NY, USA The Center for Visual Science, University of Rochester, Rochester, NY, USA.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI Susana Marcos · 1985 to 2026
$17.5M
VISUAL SCIENCET32EY007125 · NEI · UNIVERSITY OF ROCHESTER · PI Krystel R Huxlin, Duje Tadin · 1990 to 2026
$7.1M
Mechanisms of visual learning in cortical blindnessR01EY021209 · NEI · UNIVERSITY OF ROCHESTER · PI HUXLIN, KRYSTEL R · 2011 to 2014
$1.5M
Mechanisms of Visual Motion PerceptionR01EY019295 · NEI · UNIVERSITY OF ROCHESTER · PI TADIN, DUJE · 2010 to 2014
$1.3M
NEI NIH HHS EY019295NEI NIH HHS EY021209NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY019295NEI NIH HHS R01 EY021209NEI NIH HHS T32 EY007125
6 · The paper itself

Abstract

The incidence of cortically induced blindness is increasing as our population ages. The major cause of cortically induced blindness is stroke affecting the primary visual cortex. While the impact of this form of vision loss is devastating to quality of life, the development of principled, effective rehabilitation strategies for this condition lags far behind those used to treat motor stroke victims. Here we summarize recent developments in the still emerging field of visual restitution therapy, and compare the relative effectiveness of different approaches. We also draw insights into the properties of recovered vision, its limitations and likely neural substrates. We hope that these insights will guide future research and bring us closer to the goal of providing much-needed rehabilitation solutions for this patient population.

Indexed as

Blindness, CorticalHumansLearningRecovery of FunctionVisual CortexVisual Fieldsperceptual learningstrokeV1vision lossvision rehabilitation

Identifiers

PMID26659828
PMCPMC4795973

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.