ArticleJournal of cell science2016
Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis.
Article in Journal of cell science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16.bioRxiv : the preprint server for biology · 2025Article
- The value of genome-wide analysis in craniosynostosis.Frontiers in genetics · 2023Article
- IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis.JCI insight · 2021Article
- Transcriptional Regulation of Structural and Functional Adaptations in a Developing Adulthood Myocardium.Cardiology and cardiovascular medicine · 2021Article
- Bioinformatics analysis of differentially expressed genes in subchondral bone in early experimental osteoarthritis using microarray data.Journal of orthopaedic surgery and research · 2020Article
- Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.Cell reports · 2020Article
- (De)form and Function: Measuring Cellular Forces with Deformable Materials and Deformable Structures.Advanced healthcare materials · 2020Review
- Genetic Causes of Craniosynostosis: An Update.Molecular syndromology · 2019Review
- Calvarial osteoblast gene expression in patients with craniosynostosis leads to novel polygenic mouse model.PloS one · 2019Article
- Article
- Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair.Molecular medicine reports · 2017Article
- Cell Mechanics of Craniosynostosis.ACS biomaterials science & engineering · 2017Article
- Genetic advances in craniosynostosis.American journal of medical genetics. Part A · 2017Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Insulin growth factor 1 (IGF1) is a major anabolic signal that is essential during skeletal development, cellular adhesion and migration. Recent transcriptomic studies have shown that there is an upregulation in IGF1 expression in calvarial osteoblasts derived from patients with single-suture craniosynostosis (SSC). Upregulation of the IGF1 signaling pathway is known to induce increased expression of a set of osteogenic markers that previously have been shown to be correlated with contractility and migration. Although the IGF1 signaling pathway has been implicated in SSC, a correlation between IGF1, contractility and migration has not yet been investigated. Here, we examined the effect of IGF1 activation in inducing cellular contractility and migration in SSC osteoblasts using micropost arrays and time-lapse microscopy. We observed that the contractile forces and migration speeds of SSC osteoblasts correlated with IGF1 expression. Moreover, both contractility and migration of SSC osteoblasts were directly affected by the interaction of IGF1 with IGF1 receptor (IGF1R). Our results suggest that IGF1 activity can provide valuable insight for phenotype-genotype correlation in SSC osteoblasts and might provide a target for therapeutic intervention.
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Registered trials
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