ReviewOral and maxillofacial surgery2016
Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review.
Review in Oral and maxillofacial surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Medication-related osteonecrosis of the jaw associated with implant and regenerative treatments: Systematic review.Medicina oral, patologia oral y cirugia bucal · 2019Pooled it
- Interventions for managing medication-related osteonecrosis of the jaw.The Cochrane database of systematic reviews · 2017Pooled it
- Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ).The Cochrane database of systematic reviews · 2016Pooled it
- Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin.BMC oral health · 2021Article
- Analysis of Factors Associated with the Postoperative Healing of Medication-Related Osteonecrosis of the Jaw in Patients with Osteoporosis.Journal of clinical medicine · 2021Article
- Characteristics of patients with osteonecrosis of the jaw with oral versus intravenous bisphosphonate treatment.Maxillofacial plastic and reconstructive surgery · 2021Article
- The role of M1 and M2 macrophage polarization in progression of medication-related osteonecrosis of the jaw.Clinical oral investigations · 2021Article
- New Perspective for Soft Tissue Closure in Medication-Related Osteonecrosis of the Jaw (MRONJ) Using Barbed Sutures.Journal of clinical medicine · 2021Article
- Conservative Management of Medication-Related Osteonecrosis of the Jaws (MRONJ): A Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2021Article
- Adipose-Derived Stem Cells Promote Bone Coupling in Bisphosphonate-Related Osteonecrosis of the Jaw by TGF-β1.Frontiers in cell and developmental biology · 2021Article
- Oral Surgical Management of Bone and Soft Tissues in MRONJ Treatment: A Decisional Tree.Life (Basel, Switzerland) · 2020Article
- Microbial diversity in infections of patients with medication-related osteonecrosis of the jaw.Clinical oral investigations · 2019Article
- Treatment with teriparatide for advanced bisphosphonate-related osteonecrosis of the jaw around dental implants: a case report.International journal of implant dentistry · 2017Article
- Treatment of medication-related osteonecrosis of the jaws (MRONJ) with ultrasonic piezoelectric bone surgery. A case series of 20 treated sites.Oral and maxillofacial surgery · 2017Article
- Bilateral Maxillary Reconstruction Using Fibular Flap in Bisphosphonate-related Osteonecrosis.Plastic and reconstructive surgery. Global open · 2016Article
- Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report.International journal of surgery case reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurgical management of bisphosphonate-related osteonecrosis of the jaws (BRONJ) has been performed in an attempt to increase healing rates of the affected cases. This literature review aimed to identify clinical studies of surgical management of bisphosphonate-related osteonecrosis of the jaws (BRONJ) in order to assess their surgical treatment modalities, outcome and the follow-up.
methodsA search in the PubMed (Medline) database using specific terms and/or phrases as "bisphosphonate-related osteonecrosis" or "jaw osteonecrosis", and "surgical treatment" or "surgical management" was conducted in order to identify clinical trials and cases of surgical treatment of BRONJ. The review search covered the time period from 2004 to 2014. All studies identified in the search were selected according to the inclusion criteria. Relevant information was recorded according to the following items: author, year, number of patients, BRONJ clinical stage, surgical treatment modality, clinical success, and follow-up.
resultsThe initial database search yielded 345 titles. After filtering, 67 abstracts were selected culminating in 67 full text articles. A variety of surgical approach was found in this review: debridement, sequestrectomy bone resection, and bone reconstruction. Adjunctive therapies included hyperbaric oxygen, laser therapy, growth factors, and ozone.
conclusionAlthough there are many indexed studies about BRONJ, well-documented reports concerning surgical therapeutically techniques are scarce, resulting from a lack of well-established protocols. Considerable differences were found regarding sample size, surgical treatment modalities and outcomes. Clinical studies with larger number of patients and longer follow-up are required to provide best information for each surgical treatment modality and its outcomes.
Indexed as
Identifiers
26659615What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.