ArticleNanoscale research letters2015
In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice.
Article in Nanoscale research letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective.ACS nano · 2024Review
- Biotransformations and cytotoxicity of eleven graphene and inorganic two-dimensional nanomaterials using simulated digestions coupled with a triculture in vitro model of the human gastrointestinal epithelium.Environmental science. Nano · 2021Article
- Synthesis of magnetic nanocomposite microparticles for binding of chlorinated organics in contaminated water sources.Journal of applied polymer science · 2020Article
- Engineering Two-dimensional Nanomaterials to Enable Structure-Activity Relationship Studies in Nanosafety Research.NanoImpact · 2020Article
- Hexagonal Boron Nitride Functionalized with Au Nanoparticles-Properties and Potential Biological Applications.Nanomaterials (Basel, Switzerland) · 2018Article
- Toxicity evaluation of boron nitride nanospheres and water-soluble boron nitride inInternational journal of nanomedicine · 2017Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
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Abstract
The boron nitride (BN) nanoparticles, as the structural analogues of graphene, are the potential biomedicine materials because of the excellent biocompatibility, but their solubility and biosafety are the biggest obstacle for the clinic application. Here, we first synthesized the highly soluble BN nanoparticles coated by PEG (BN-PEG) with smaller size (~10 nm), then studied their biodistribution in vivo through radioisotope (Tc(99m)O4 (-)) labeling, and the results showed that BN-PEG nanoparticles mainly accumulated in the liver, lung, and spleen with the less uptake by the brain. Moreover, the pathological changes induced by BN-PEG could be significantly observed in the sections of the liver, lung, spleen, and heart, which can be also supported by the test of biochemical indexes in serum. More importantly, we first observed the biodistribution of BN-PEG in the heart tissues with high toxicity, which would give a warning about the cardiovascular disease, and provide some opportunities for the drug delivery and treatment.
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