ArticleAJNR. American journal of neuroradiology2016
Multicenter Validation of Mean Upper Cervical Cord Area Measurements from Head 3D T1-Weighted MR Imaging in Patients with Multiple Sclerosis.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spinal cord imaging in multiple sclerosis: A vital component we can no longer overlook.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Pooled it
- Neural correlates of digital measures shown by structural MRI: a post-hoc analysis of a smartphone-based remote assessment feasibility study in multiple sclerosis.Journal of neurology · 2023Trial
- The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis.European radiology · 2022Trial
- Charting Cervical Spinal Cord Morphometry Across the Lifespan.Human brain mapping · 2026Article
- Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Charting Cervical Spinal Cord Morphometry Across the Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Super-Resolution in Clinically Available Spinal Cord MRIs Enables Automated Atrophy Analysis.AJNR. American journal of neuroradiology · 2025Article
- Aerobic capacity moderates the association between cervical cord atrophy and clinical disability in mildly disabled multiple sclerosis patients.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Optimization of cervical cord atrophy measurement using a real-world, multicentre dataset in multiple sclerosis.Frontiers in neurology · 2025Article
- Validation of a New Semiautomated Segmentation Pipeline Based on the Spinal Cord Toolbox DeepSeg Algorithm to Estimate the Cervical Canal Area.AJNR. American journal of neuroradiology · 2023Article
- Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions.NeuroImage. Clinical · 2022Review
- Quantification of Cervical Cord Cross-Sectional Area: Which Acquisition, Vertebra Level, and Analysis Software? A Multicenter Repeatability Study on a Traveling Healthy Volunteer.Frontiers in neurology · 2021Article
- The sequence of structural, functional and cognitive changes in multiple sclerosis.NeuroImage. Clinical · 2021Article
- Considerations for Mean Upper Cervical Cord Area Implementation in a Longitudinal MRI Setting: Methods, Interrater Reliability, and MRI Quality Control.AJNR. American journal of neuroradiology · 2020Article
- Spinal cord atrophy in a primary progressive multiple sclerosis trial: Improved sample size using GBSI.NeuroImage. Clinical · 2020Article
- Validation of mean upper cervical cord area (MUCCA) measurement techniques in multiple sclerosis (MS): High reproducibility and robustness to lesions, but large software and scanner effects.NeuroImage. Clinical · 2019Article
- Advances in spinal cord imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019Review
- MRI-Based Methods for Spinal Cord Atrophy Evaluation: A Comparison of Cervical Cord Cross-Sectional Area, Cervical Cord Volume, and Full Spinal Cord Volume in Patients with Aquaporin-4 Antibody Seropositive Neuromyelitis Optica Spectrum Disorders.AJNR. American journal of neuroradiology · 2018Article
- Future Brain and Spinal Cord Volumetric Imaging in the Clinic for Monitoring Treatment Response in MS.Current treatment options in neurology · 2018Review
- Cervical spinal cord atrophy: An early marker of progressive MS onset.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSpinal cord atrophy is a common and clinically relevant characteristic in multiple sclerosis. We aimed to perform a multicenter validation study of mean upper cervical cord area measurements in patients with multiple sclerosis and healthy controls from head MR images and to explore the effect of gadolinium administration on mean upper cervical cord area measurements. MATERIALS AND
methodsWe recruited 97 subjects from 3 centers, including 60 patients with multiple sclerosis of different disease types and 37 healthy controls. Both cervical cord and head 3D T1-weighted images were acquired. In 11 additional patients from 1 center, head images before and after gadolinium administration and cervical cord images after gadolinium administration were acquired. The mean upper cervical cord area was compared between cervical cord and head images by using intraclass correlation coefficients (ICC) for both consistency (ICCconsist) and absolute (ICCabs) agreement.
resultsThere was excellent agreement of mean upper cervical cord area measurements from head and cervical cord images in the entire group (ICCabs = 0.987) and across centers and disease subtypes. The mean absolute difference between the mean upper cervical cord area measured from head and cervical cord images was 2 mm(2) (2.3%). Additionally, excellent agreement was found between the mean upper cervical cord area measured from head images with and without gadolinium administration (ICCabs = 0.991) and between the cervical cord and head images with gadolinium administration (ICCabs = 0.992).
conclusionsExcellent agreement between mean upper cervical cord area measurements on head and cervical cord images was observed in this multicenter study, implying that upper cervical cord atrophy can be reliably measured from head images. Postgadolinium head or cervical cord images may also be suitable for measuring mean upper cervical cord area.
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