Evidence map›Paper›PMID 26658763›Full record

ArticleEuropean journal of nutrition2017

N- and S-homocysteinylation reduce the binding of human serum albumin to catechins.

Angelo Zinellu, Salvatore Sotgia, Bastianina Scanu, Dionigia Arru, Annalisa Cossu, Anna Maria Posadino, Roberta Giordo, Arduino A Mangoni, Gianfranco Pintus, Ciriaco Carru

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Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Serum Albumin: A Multifaced Enzyme.International journal of molecular sciences · 2021
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Angelo ZinelluDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy. azinellu@uniss.it.
Salvatore SotgiaDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Bastianina ScanuDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Dionigia ArruDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Annalisa CossuDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Anna Maria PosadinoDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Roberta GiordoDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Arduino A MangoniDepartment of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia.
Gianfranco PintusDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Ciriaco CarruDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy. carru@uniss.it.
University of Sassari · ITFlinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe dietary flavonoids epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) have been shown to interact with circulating albumin for transport in blood to different body tissues. This interaction may modulate their bioavailability and effectiveness.

methodsUsing affinity capillary electrophoresis to assess binding constants (K

resultsS-Hcy HSA had lower K

conclusionTherefore, HSA posttranslational modifications typical of hyperhomocysteinemia reduce its affinity to catechins, potentially affecting their pharmacokinetics and availability at the active sites.

Indexed as

Protein Processing, Post-TranslationalAminoacylationCatechinCysteineElectrophoresis, CapillaryHomocysteineHumansHyperhomocysteinemiaKineticsLigandsLysineSerum AlbuminSerum Albumin, HumanALB protein, humanCatechinCysteineepicatechin gallateepigallocatechin gallategallocatecholHomocysteinehomocysteine thiolactoneLigandsLysinemercaptoalbuminSerum AlbuminSerum Albumin, HumanAffinity capillary electrophoresisAlbuminBinding constantCatechins

Identifiers

PMID26658763
OpenAlexW2289799512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.