ArticleInternational urogynecology journal2016
Elastin density: Link between histological and biomechanical properties of vaginal tissue in women with pelvic organ prolapse?
Article in International urogynecology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Raman spectroscopy for nondestructive detection of vaginal tissue alterations in the fibulin-5 murine model of pelvic organ prolapse.Biophotonics discovery · 2026Article
- Decellularization method and tissue region impact the structural properties and composition of porcine vaginal extracellular matrix.Acta biomaterialia · 2026Article
- Vaginal Fibroblast Behavior as a Function of Stiffness Changes in a Polyisocyanide Hydrogel for Prolapse Repair.ACS applied bio materials · 2023Article
- Non-invasive biomechanical assessment of the prolapsed vaginal wall: an explorative pilot study on cutometry and indentometry.Scientific reports · 2023Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- Quantitative Morphometry of Elastic Fibers in Pelvic Organ Prolapse.Annals of biomedical engineering · 2021Article
- Pelvic Organ Prolapse: A Review of In Vitro Testing of Pelvic Support Mechanisms.Ochsner journal · 2020Review
- Article
- Development of anatomically based customizable three-dimensional finite-element model of pelvic floor support system: POP-SIM1.0.Interface focus · 2019Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThe aim of the study was to correlate histological and biomechanical characteristics of the vaginal wall in women with pelvic organ prolapse (POP).
methodsTissue samples were collected from the anterior [point Ba; POP Questionnaire (POP-Q)] and/or posterior (point Bp; POP-Q) vaginal wall of 15 women who underwent vaginal surgery for POP. Both histological and biomechanical assessments were performed from the same tissue samples in 14 of 15 patients. For histological assessment, the density of collagen and elastin fibers was determined by combining high-resolution virtual imaging and computer-assisted digital image analysis. For biomechanical testing, uniaxial tension tests were performed to evaluate vaginal tissue stiffness at low (C0) and high (C1) deformation rates.
resultsBiomechanical testing highlights the hyperelastic behavior of the vaginal wall. At low strains (C0), vaginal tissue appeared stiffer when elastin density was low. We found a statistically significant inverse relationship between C0 and the elastin/collagen ratio (p = 0.048) in the lamina propria. However, at large strain levels (C1), no clear relationship was observed between elastin density or elastin/collagen ratio and stiffness, likely reflecting the large dispersion of the mechanical behavior of the tissue samples.
conclusionHistological and biomechanical properties of the vaginal wall vary from patient to patient. This study suggests that elastin density deserves consideration as a relevant factor of vaginal stiffness in women with POP.
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