ArticlePLoS genetics2015
Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Acetylated Vps1 initiates autophagy and regulates the sorting nexin dynamics essential for pathogenicity inAutophagy · 2026Article
- Retromer Regulates Macro- and Micro-Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Harnessing the Tet-Off system for effective gene silencing inFrontiers in plant science · 2025Article
- The Sorting and Transport of the Cargo Protein CcSnc1 by the Retromer Complex Regulate the Growth, Development, and Pathogenicity ofJournal of fungi (Basel, Switzerland) · 2024Article
- PARylation of 14-3-3 proteins controls the virulence of Magnaporthe oryzae.Nature communications · 2024Article
- Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease.Cell death discovery · 2024Article
- Attenuation of phytofungal pathogenicity of Ascomycota by autophagy modulators.Nature communications · 2024Article
- A novel partitivirus conferring hypovirulence by affecting vesicle transport in the fungusmBio · 2024Article
- Molecular basis for loss of virulence inFrontiers in plant science · 2024Article
- DAP1 regulates osteoblast autophagy via the ATG16L1-LC3 axis in Graves' disease-induced osteoporosis.Journal of orthopaedic surgery and research · 2023Article
- Article
- HOG1 Mitogen-Activated Protein Kinase Pathway-Related Autophagy Induced by HJournal of fungi (Basel, Switzerland) · 2023Article
- The Devastating Rice Blast Airborne PathogenPathogens (Basel, Switzerland) · 2023Review
- Acyl-coenzyme A binding protein MoAcb1 regulates conidiation and pathogenicity inFrontiers in microbiology · 2023Article
- MoMih1 is indispensable for asexual development, cell wall integrity, and pathogenicity ofFrontiers in plant science · 2023Article
- Retromer subunit, CfVps35 is required for growth development and pathogenicity of Colletotrichum fructicola.BMC genomic data · 2022Article
- The Sorting Nexin GenesJournal of fungi (Basel, Switzerland) · 2022Article
- The Retromer Subunit CfVps29 Is Involved in the Growth, Development, and Pathogenicity ofJournal of fungi (Basel, Switzerland) · 2022Article
- Casein Kinase 2 Mediates Degradation of Transcription Factor Pcf1 during Appressorium Formation in the Rice Blast Fungus.Journal of fungi (Basel, Switzerland) · 2022Article
- Autophagy as a Survival Strategy for Eukaryotic Microbes Living in the Phyllosphere.Frontiers in plant science · 2022Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retromer mediates protein trafficking through recycling cargo from endosomes to the trans-Golgi network in eukaryotes. However, the role of such trafficking events during pathogen-host interaction remains unclear. Here, we report that the cargo-recognition complex (MoVps35, MoVps26 and MoVps29) of the retromer is essential for appressorium-mediated host penetration by Magnaporthe oryzae, the causal pathogen of the blast disease in rice. Loss of retromer function blocked glycogen distribution and turnover of lipid bodies, delayed nuclear degeneration and reduced turgor during appressorial development. Cytological observation revealed dynamic MoVps35-GFP foci co-localized with autophagy-related protein RFP-MoAtg8 at the periphery of autolysosomes. Furthermore, RFP-MoAtg8 interacted with MoVps35-GFP in vivo, RFP-MoAtg8 was mislocalized to the vacuole and failed to recycle from the autolysosome in the absence of the retromer function, leading to impaired biogenesis of autophagosomes. We therefore conclude that retromer is essential for autophagy-dependent plant infection by the rice blast fungus.
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