ArticleScientific reports2015
Successful treatment of biofilm infections using shock waves combined with antibiotic therapy.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 74 citations in OpenAlex.
- Treatment of Methicillin-ResistantMedicines (Basel, Switzerland) · 2026Review
- Diode Laser-Guided Protocol for Endo-Perio Lesions: Toward a Multi-Stage Therapeutic Strategy-A Case Series and Brief Literature Review.Medicina (Kaunas, Lithuania) · 2025Review
- Emerging Therapies in Chronic Wound Healing: Advances in Stem Cell Therapy, Growth Factor Modulation, Mechanical Strategies and Adjuvant Interventions.Dermatology and therapy · 2025Review
- Investigation of shockwave treatment for disruption of bacterial biofilm on tubular structure.Scientific reports · 2025Article
- Low-energy shock waves improve the bacterial detection of Staphylococcus aureus biofilms on polyethylene.Scientific reports · 2025Article
- Biofilm Producing Methicillin-ResistantPathogens (Basel, Switzerland) · 2024Review
- Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies.Frontiers in cell and developmental biology · 2022Review
- Chitosan-Based Hydrogel for the Dual Delivery of Antimicrobial Agents Against Bacterial Methicillin-ResistantACS omega · 2021Article
- Antibiofilm efficacy of focused high-energy extracorporeal shockwaves and antibiotics in vitro.Bone & joint research · 2021Article
- Nanomaterials for Treating Bacterial Biofilms on Implantable Medical Devices.Nanomaterials (Basel, Switzerland) · 2020Review
- Evaluation of Viable Cells inBio-protocol · 2020Article
- Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections.Ultrasound in medicine & biology · 2020Review
- Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care.Biofilm · 2019Article
- Immobilization-Enhanced Eradication of Bacterial Biofilms and in situ Antimicrobial Coating of Implant Material Surface - an in vitro Study.International journal of nanomedicine · 2019Article
- Shockwave Therapy Efficiently Cures Multispecies Chronic Periodontitis in a Humanized Rat Model.Frontiers in bioengineering and biotechnology · 2019Article
- Automated classification platform for the identification of otitis media using optical coherence tomography.NPJ digital medicine · 2019Article
- Sensitizing bacterial cells to antibiotics by shape recovery triggered biofilm dispersion.Acta biomaterialia · 2018Article
- Stimulation of angiogenesis using single-pulse low-pressure shock wave treatment.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms.Nature communications · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many bacteria secrete a highly hydrated framework of extracellular polymer matrix on suitable substrates and embed within the matrix to form a biofilm. Bacterial biofilms are observed on many medical devices, endocarditis, periodontitis and lung infections in cystic fibrosis patients. Bacteria in biofilm are protected from antibiotics and >1,000 times of the minimum inhibitory concentration may be required to treat biofilm infections. Here, we demonstrated that shock waves could be used to remove Salmonella, Pseudomonas and Staphylococcus biofilms in urinary catheters. The studies were extended to a Pseudomonas chronic pneumonia lung infection and Staphylococcus skin suture infection model in mice. The biofilm infections in mice, treated with shock waves became susceptible to antibiotics, unlike untreated biofilms. Mice exposed to shock waves responded to ciprofloxacin treatment, while ciprofloxacin alone was ineffective in treating the infection. These results demonstrate for the first time that, shock waves, combined with antibiotic treatment can be used to treat biofilm infection on medical devices as well as in situ infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.