ArticleMolecular biology of the cell2016
Cells activated for wound repair have the potential to direct collective invasion of an epithelium.
Article in Molecular biology of the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Supervised Machine-Based Learning and Computational Analysis to Reveal Unique Molecular Signatures Associated with Wound Healing and Fibrotic Outcomes to Lens Injury.International journal of molecular sciences · 2025Article
- Vimentin - Force regulator in confined environments.Current opinion in cell biology · 2025Review
- Differential Impacts on Proteoglycan Expression in the Response to Lens Wounding in Reparative and Pro-fibrotic Microenvironments.Proteoglycan research · 2025Article
- Spiroconjugated 1,2,3-triazolo[5,1-Research in pharmaceutical sciences · 2024Article
- Immune Responses Induced at One Hour Post Cataract Surgery Wounding of the Chick Lens.Biomolecules · 2023Article
- Article
- The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner.Biomolecules · 2022Article
- The Pro-fibrotic Response of Mesenchymal Leader Cells to Lens Wounding Involves Hyaluronic Acid, Its Receptor RHAMM, and Vimentin.Frontiers in cell and developmental biology · 2022Article
- Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling.Frontiers in cell and developmental biology · 2022Review
- The local wound environment is a key determinant of the outcome of TGFβ signaling on the fibrotic response of CD44Experimental eye research · 2021Article
- Vimentin Cytoskeleton Architecture Analysis on Polylactide and Polyhydroxyoctanoate Substrates for Cell Culturing.International journal of molecular sciences · 2021Article
- Resident immune cells of the avascular lens: Mediators of the injury and fibrotic response of the lens.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue.Nature communications · 2020Article
- Fibrosis: Shared Lessons From the Lens and Cornea.Anatomical record (Hoboken, N.J. : 2007) · 2020Review
- DeepScratch: Single-cell based topological metrics of scratch wound assays.Computational and structural biotechnology journal · 2020Article
- Calcium Oscillatory Behavior and Its Possible Role during Wound Healing in Bovine Corneal Endothelial Cells in Culture.BioMed research international · 2019Article
- In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype.Molecular biology of the cell · 2018Article
- Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.PloS one · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mechanisms regulating how groups of cells are signaled to move collectively from their original site and invade surrounding matrix are poorly understood. Here we develop a clinically relevant ex vivo injury invasion model to determine whether cells involved in directing wound healing have invasive function and whether they can act as leader cells to direct movement of a wounded epithelium through a three-dimensional (3D) extracellular matrix (ECM) environment. Similar to cancer invasion, we found that the injured cells invade into the ECM as cords, involving heterotypical cell-cell interactions. Mesenchymal cells with properties of activated repair cells that typically locate to a wound edge are present in leader positions at the front of ZO-1-rich invading cords of cells, where they extend vimentin intermediate filament-enriched protrusions into the 3D ECM. Injury-induced invasion depends on both vimentin cytoskeletal function and MMP-2/9 matrix remodeling, because inhibiting either of these suppressed invasion. Potential push and pull forces at the tips of the invading cords were revealed by time-lapse imaging, which showed cells actively extending and retracting protrusions into the ECM. This 3D injury invasion model can be used to investigate mechanisms of leader cell-directed invasion and understand how mechanisms of wound healing are hijacked to cause disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.