Evidence map›Paper›PMID 26658612›Full record

ArticleMolecular biology of the cell2016

APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.

Kate M Mills, Mariana G Brocardo, Beric R Henderson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. YTHDF3 Promoted Gastric Cancer Progression by Facilitating mAnalytical cellular pathology (Amsterdam) · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Miro proteins and their role in mitochondrial transfer in cancer and beyond.Frontiers in cell and developmental biology · 2022
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Mitochondrial dynamics and metastasis.Cellular and molecular life sciences : CMLS · 2019
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kate M MillsCentre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Mariana G BrocardoCentre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia beric.henderson@sydney.edu.au mariana.brocardo@sydney.edu.au.
Beric R HendersonCentre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia beric.henderson@sydney.edu.au mariana.brocardo@sydney.edu.au.
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in adenomatous polyposis coli (APC) disrupt regulation of Wnt signaling, mitosis, and the cytoskeleton. We describe a new role for APC in the transport of mitochondria. Silencing of wild-type APC by small interfering RNA caused mitochondria to redistribute from the cell periphery to the perinuclear region. We identified novel APC interactions with the mitochondrial kinesin-motor complex Miro/Milton that were mediated by the APC C-terminus. Truncating mutations in APC abolished its ability to bind Miro/Milton and reduced formation of the Miro/Milton complex, correlating with disrupted mitochondrial distribution in colorectal cancer cells that could be recovered by reconstitution of wild-type APC. Using proximity ligation assays, we identified endogenous APC-Miro/Milton complexes at mitochondria, and live-cell imaging showed that loss of APC slowed the frequency of anterograde mitochondrial transport to the membrane. We propose that APC helps drive mitochondria to the membrane to supply energy for cellular processes such as directed cell migration, a process disrupted by cancer mutations.

Indexed as

Adenomatous Polyposis Coli ProteinAnimalsBiological TransportCarrier ProteinsCell Line, TumorCell MembraneHumansIntracellular Signaling Peptides and ProteinsMiceMicrotubulesMitochondriaMitochondrial ProteinsMutationNeoplasmsNerve Tissue ProteinsNIH 3T3 CellsAdenomatous Polyposis Coli ProteinAPC protein, humanCarrier ProteinsIntracellular Signaling Peptides and ProteinsMitochondrial ProteinsNerve Tissue Proteinsrho GTP-Binding ProteinsRHOT1 protein, humanTRAK2 protein, human

Identifiers

PMID26658612
PMCPMC4751598
OpenAlexW2253405732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.