Evidence map›Paper›PMID 26658555›Full record

ArticleLight, science & applications2015

Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation.

Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Christine M Sorenson, Amani A Fawzi, Robert A Linsenmeier, Hao F Zhang

Open access · goldAbstract read
In one paragraph

Article in Light, science & applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 180 citations in OpenAlex.

  1. Article
  2. Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ji YiDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Wenzhong LiuDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Siyu ChenDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Vadim BackmanDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Nader SheibaniMcPherson Eye Research Institute, University of Wisconsin, Madison, WI 53705, USA.
Christine M SorensonMcPherson Eye Research Institute, University of Wisconsin, Madison, WI 53705, USA.
Amani A FawziDepartment of Ophthalmology, Northwestern University, Chicago Illinois 60611, USA.
Robert A LinsenmeierDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA ; Department of Ophthalmology, Northwestern University, Chicago Illinois 60611, USA ; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA ; Department of Ophthalmology, Northwestern University, Chicago Illinois 60611, USA.
Northwestern University · USSmith-Kettlewell Eye Research Institute · US

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
Novel Antiangiogenic Peptides for Treatment of Exudative AMDR24EY022883 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SHEIBANI, NADER · 2013 to 2017
$6.2M
Multimodal Retinal Functional Imaging for Diabetic RetinopathyR01EY019951 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAWZI, AMANI A, JIAO, SHULIANG · 2011 to 2015
$3.0M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY019951NEI NIH HHS R24 EY022883NIDDK NIH HHS DP3 DK108248
6 · The paper itself

Abstract

The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Using visible light optical coherence tomography (vis-OCT), we demonstrated accurate and robust measurement of retinal oxygen metabolic rate (rMRO

Indexed as

oxygen metabolismretinal circulationvisible light optical coherence tomography

Identifiers

PMID26658555
PMCPMC4674267
OpenAlexW2210198236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.