ArticleScientific reports2015
Corresponding morphological and molecular indicators of crude oil toxicity to the developing hearts of mahi mahi.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 109 citations in OpenAlex.
- Trophic transfer and bioaccumulation of nanoplastics in Coryphaena hippurus (mahi-mahi) and effect of depuration.PloS one · 2024Article
- Biological Responses of Pacific Herring Embryos to Crude Oil Are Quantifiable at Exposure Levels Below Conventional Limits of Quantitation for PAHs in Water and Tissues.Environmental science & technology · 2023Article
- Morphological and cardiac alterations after crude oil exposure in the early-life stages of the tropical gar (Atractosteus tropicus).Environmental science and pollution research international · 2022Article
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- A review of the toxicology of oil in vertebrates: what we have learned following theJournal of toxicology and environmental health. Part B, Critical reviews · 2021Review
- Exposure to the natural alkaloid Berberine affects cardiovascular system morphogenesis and functionality during zebrafish development.Scientific reports · 2020Article
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- Embryonic Crude Oil Exposure Impairs Growth and Lipid Allocation in a Keystone Arctic Forage Fish.iScience · 2019Article
- Oil exposure alters social group cohesion in fish.Scientific reports · 2019Article
- Chronic toxicity of oil sands tailings pond sediments to early life stages of fathead minnow (Heliyon · 2019Article
- Mahi-mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Article
- Morphology and cardiac physiology are differentially affected by temperature in developing larvae of the marine fish mahi-mahi (Biology open · 2017Article
- Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil.Scientific reports · 2017Article
- Crude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac development.Scientific reports · 2016Article
- Phenoscape: Identifying Candidate Genes for Evolutionary Phenotypes.Molecular biology and evolution · 2016Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crude oils from distinct geological sources worldwide are toxic to developing fish hearts. When oil spills occur in fish spawning habitats, natural resource injury assessments often rely on conventional morphometric analyses of heart form and function. The extent to which visible indicators correspond to molecular markers for cardiovascular stress is unknown for pelagic predators from the Gulf of Mexico. Here we exposed mahi (Coryphaena hippurus) embryos to field-collected crude oil samples from the 2010 Deepwater Horizon disaster. We compared visible heart defects (edema, abnormal looping, reduced contractility) to changes in expression of cardiac-specific genes that are diagnostic of heart failure in humans or associated with loss-of-function zebrafish cardiac mutants. Mahi exposed to crude oil during embryogenesis displayed typical symptoms of cardiogenic syndrome as larvae. Contractility, looping, and circulatory defects were evident, but larval mahi did not exhibit downstream craniofacial and body axis abnormalities. A gradation of oil exposures yielded concentration-responsive changes in morphometric and molecular responses, with relative sensitivity being influenced by age. Our findings suggest that 1) morphometric analyses of cardiac function are more sensitive to proximal effects of crude oil-derived chemicals on the developing heart, and 2) molecular indicators reveal a longer-term adverse shift in cardiogenesis trajectory.
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