ArticleNature protocols2016
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
Article in Nature protocols, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed.
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- Chronic intermittent hypoxia reshapes circadian metabolic architecture in a model of sleep apnea.Science advances · 2026Article
- A filamentary soft robotic probe for multimodal in utero monitoring of fetal health.Nature biomedical engineering · 2026Article
- HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload.Frontiers in pharmacology · 2026Article
- Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells.bioRxiv : the preprint server for biology · 2025Article
- Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons.Nature communications · 2024Article
- Feeding behavior modifies the circadian variation in RR and QT intervals by distinct mechanisms in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- What to consider for ECG in mice-with special emphasis on telemetry.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes.Frontiers in physiology · 2023Article
- Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains.JCI insight · 2022Article
- Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability.Nature protocols · 2022Review
- Article
- Age and Gender Differences in Cardiovascular Autonomic Failure in the Transgenic PLP-syn Mouse, a Model of Multiple System Atrophy.Frontiers in neurology · 2022Article
- Aging Alters the Formation and Functionality of Signaling Microdomains Between L-type Calcium Channels and β2-Adrenergic Receptors in Cardiac Pacemaker Cells.Frontiers in physiology · 2022Article
- Heart Rate Variability Reveals Altered Autonomic Regulation in Response to Myocardial Infarction in Experimental Animals.Frontiers in cardiovascular medicine · 2022Article
- The Role of POPDC Proteins in Cardiac Pacemaking and Conduction.Journal of cardiovascular development and disease · 2021Review
- Moving average and standard deviation thresholding (MAST): a novel algorithm for accurate R-wave detection in the murine electrocardiogram.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice.Journal of visualized experiments : JoVE · 2021Article
- Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing.Nature communications · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The normal heartbeat slightly fluctuates around a mean value; this phenomenon is called physiological heart rate variability (HRV). It is well known that altered HRV is a risk factor for sudden cardiac death. The availability of genetic mouse models makes it possible to experimentally dissect the mechanism of pathological changes in HRV and its relation to sudden cardiac death. Here we provide a protocol that allows for a comprehensive multilevel analysis of heart rate (HR) fluctuations. The protocol comprises a set of techniques that include in vivo telemetry and in vitro electrophysiology of intact sinoatrial network preparations or isolated single sinoatrial node (SAN) cells. In vitro preparations can be completed within a few hours, with data acquisition within 1 d. In vivo telemetric ECG requires 1 h for surgery and several weeks for data acquisition and analysis. This protocol is of interest to researchers investigating cardiovascular physiology and the pathophysiology of sudden cardiac death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.