ArticleScientific reports2015
Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Lipase-mediated detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus.Communications biology · 2024Article
- β-Hemolysin, notmSphere · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Article
- Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species.Communications biology · 2023Article
- New insight into the virulence and inflammatory response ofFrontiers in cellular and infection microbiology · 2023Article
- Genotypes ofToxins · 2022Article
- Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Article
- Direct identification of bacterial and human proteins from infected wounds in living 3D skin models.Scientific reports · 2020Article
- Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions.Science translational medicine · 2018Article
- Defining motility in the Staphylococci.Cellular and molecular life sciences : CMLS · 2017Review
- Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading.PloS one · 2016Article
- The multifaceted helical net of amphipathic alpha-helices; the next dimension of the helical peptide wheel.Science progressArticle
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Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
Abstract
Staphylococcus aureus δ-toxin is a member of the phenol-soluble modulin (PSM) peptide family. PSMs have multiple functions in staphylococcal pathogenesis; for example, they lyse red and white blood cells and trigger inflammatory responses. Compared to other PSMs, δ-toxin is usually more strongly expressed but has only moderate cytolytic capacities. The amino acid sequences of S. aureus PSMs are well conserved with two exceptions, one of which is the δ-toxin allelic variant G10S. This variant is a characteristic of the subspecies S. argenteus and S. aureus sequence types ST1 and ST59, the latter representing the most frequent cause of community-associated infections in Asia. δ-toxin G10S and strains expressing that variant from plasmids or the genome had significantly reduced cytolytic and pro-inflammatory capacities, including in a strain background with pronounced production of other PSMs. However, in murine infection models, isogenic strains expressing the two δ-toxin variants did not cause measurable differences in disease severity. Our findings indicate that the widespread G10S allelic variation of the δ-toxin locus has a significant impact on key pathogenesis mechanisms, but more potent members of the PSM peptide family may overshadow that impact in vivo.
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