ArticleThe Pediatric infectious disease journal2016
Influenza Vaccine is Protective Against Laboratory-confirmed Influenza in Obese Children.
Article in The Pediatric infectious disease journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Females with Obesity Exhibit Greater Influenza Vaccine-induced Immunity and Protection than Males in a Mouse Model.bioRxiv : the preprint server for biology · 2025Article
- Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model.Frontiers in immunology · 2025Article
- Elevated body mass index is not significantly associated with reduced influenza vaccine effectiveness.Scientific reports · 2024Article
- SARS-CoV-2 and Influenza Vaccines in People with Excessive Body Mass-A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Obesity and immune status in children.Current opinion in pediatrics · 2020Review
- Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients.Biology · 2020Review
- Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs.Journal of virology · 2019Review
- Influenza in obese travellers: increased risk and complications, decreased vaccine effectiveness.Journal of travel medicine · 2019Review
- Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution.Frontiers in immunology · 2019Review
- Preliminary results of official influenza and acute respiratory infection surveillance in two towns of Burkina Faso, 2013-2015.BMC infectious diseases · 2018Article
- Article
- Increased risk of influenza among vaccinated adults who are obese.International journal of obesity (2005) · 2017Observational
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundObesity emerged as a novel risk factor for severe disease during the 2009 H1N1 influenza pandemic. Murine studies indicate that obesity is associated with ineffective response to influenza vaccine, but few human studies exist. We aimed to determine if influenza vaccine is protective against laboratory-confirmed influenza in obese children.
methodsBody mass index, vaccination status, and laboratory-confirmed influenza data were analyzed from a previously conducted prospective study in which active surveillance for influenza-like illness was conducted in 8 elementary schools in Los Angeles County during the 2010-2011 influenza season. Polymerase-chain reaction (PCR) was performed on combined nose/throat swabs collected from children with influenza-like illness at presentation to the school nurse or during absenteeism.
resultsOf 4260 children with height/weight data, 1191 (28.0%) were obese (body mass index ≥95th percentile). Respiratory specimens were obtained from 858 (20.1%) children. Unvaccinated obese compared with vaccinated obese children acquired 3 times more PCR-confirmed influenza (62 vs. 17 per 1000 children, P = 0.003) and missed more school days (4.6 vs. 3.2 per 100 school days, P < 0.001) during influenza season. Obese children with PCR-confirmed influenza were more likely to present with cough (86.2 vs. 72.4%, P = 0.030) and missed more school per episode (2.4 vs.1.9 days, P = 0.023) compared with nonobese children. Among vaccinated children, rates of PCR-confirmed influenza were similar in obese and nonobese children (17 vs. 20 per 1000 children, P = 0.77).
conclusionsObese children with PCR-confirmed influenza suffered from more cough and missed more school days than their nonobese peers. Influenza vaccination protected obese children against PCR-proven influenza illness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.