SynthesisPloS one2015
Endoscopic Resection Compared with Gastrectomy to Treat Early Gastric Cancer: A Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Association between neutrophil-lymphocyte ratio and lymph node metastasis in gastric cancer: A meta-analysis.Medicine · 2022Pooled it
- Laparoscopic versus open subtotal gastrectomy for gastric adenocarcinoma: cost-effectiveness analysis.BJS open · 2020Pooled it
- A machine learning-based predictive model for lymph node metastasis in elderly patients with early gastric cancer and prognosis.Updates in surgery · 2026Article
- Article
- Nomogram for pre-procedural prediction of lymph node metastasis in patients with submucosal early gastric cancer.Surgical endoscopy · 2025Article
- Early Detection of Malignant Cells in Gastric Lavage via Hexokinase 2 and Single-Cell Sequencing for Gastric Cancer Diagnosis.Risk management and healthcare policy · 2025Article
- Risk of Gastric Adenocarcinoma in a Multiethnic Population Undergoing Routine Care: An Electronic Health Records Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Population effectiveness of endoscopy screening for mortality reduction in gastric cancer.DEN open · 2024Article
- Nomogram for pre-procedural prediction of non-curative endoscopic resection in patients with early gastric cancer.Surgical endoscopy · 2023Article
- Associate factors for endoscopic submucosal dissection operation time and postoperative delayed hemorrhage of early gastric cancer.World journal of gastrointestinal surgery · 2023Article
- Lymph node involvement in gastric adenocarcinoma.Surgical endoscopy · 2022Article
- Advances in screening and detection of gastric cancer.Journal of surgical oncology · 2022Review
- Early gastric cancer: A challenge in Western countries.World journal of gastroenterology · 2022Article
- Clinicopathological significance of primitive phenotypes in early gastric cancer with differentiated histology.Diagnostic pathology · 2021Article
- Impact of the Interval between Previous Endoscopic Exam and Diagnosis on the Mortality and Treatment Modality of Undifferentiated-Type Gastric Cancer.Journal of gastric cancer · 2021Article
- A Novel Self-Assembled Gel for Gastric Endoscopic Submucosal Dissection-Induced Ulcer: A Preclinical Study in a Porcine Model.Frontiers in pharmacology · 2021Article
- A population-based study: how to identify high-risk T1 gastric cancer patients?American journal of cancer research · 2021Article
- Upper Endoscopy up to 3 Years Prior to a Diagnosis of Gastric Cancer Is Associated With Lower Stage of Disease in a USA Multiethnic Urban Population, a Retrospective Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2019Article
- Predictive Factors for Lymph Node Metastasis and the Effect on Survival in Early Gastric Cancer Patients with Radical Gastric Resection.Sisli Etfal Hastanesi tip bulteni · 2019Article
- Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic resection and gastrectomy are treatment modalities for early gastric cancer, but their relative benefits and risks are unclear. We conducted a systematic review and meta-analysis to compare endoscopic resection and gastrectomy for treating early gastric cancer.
methodsWe searched PubMed, Embase, and the Cochrane Library until April 2015 for studies comparing endoscopic resection with gastrectomy for treatment of early gastric cancer. Outcome measures were five-year overall survival (OS), length of hospital stay and postoperative morbidity. We calculated pooled hazard ratio (HR), weighted mean difference (WMD) and odds ratio (OR) using random effects models.
resultsSix studies comprising 1,466 patients (618 endoscopic resection and 848 gastrectomy) met inclusion criteria. Five-year OS was similar between endoscopic resection and gastrectomy (HR, 1.06; 95% CI: 0.61 to 1.83). Endoscopic resection was associated with shorter hospital stays (WMD, -6.94; 95% CI: -7.59 to -6.29) and reduced overall postoperative morbidity (OR, 0.36; 95% CI: 0.17 to 0.74).
conclusionsWhile five-year OS is similar between endoscopic resection and gastrectomy, endoscopic resection offers a shorter hospital stay and fewer complications than gastrectomy for treating early gastric cancer. Endoscopic resection is a reasonable treatment for early gastric cancer with a negligible risk of lymph node metastasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.