ArticlePloS one2015
Structural and Functional Brain Remodeling during Pregnancy with Diffusion Tensor MRI and Resting-State Functional MRI.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Peripartum sertraline impacts maternal neurobehavioral and neurodegenerative mechanisms in pregnant and postpartum mice.Molecular psychiatry · 2025Article
- Longitudinal investigation of neurobiological changes across pregnancy.Communications biology · 2025Article
- The transition to motherhood: linking hormones, brain and behaviour.Nature reviews. Neuroscience · 2023Review
- Sex Hormones, Sleep, and Memory: Interrelationships Across the Adult Female Lifespan.Frontiers in aging neuroscience · 2022Review
- Recent Neuroscience Advances in Human Parenting.Advances in neurobiology · 2022Article
- A history of previous childbirths is linked to women's white matter brain age in midlife and older age.Human brain mapping · 2021Article
- Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition.Scientific reports · 2021Article
- Structural Alterations in a Rat Model of Short-Term Conductive Hearing Loss Are Associated With Reduced Resting State Functional Connectivity.Frontiers in systems neuroscience · 2021Article
- Characterizing the Brain Structural Adaptations Across the Motherhood Transition.Frontiers in global women's health · 2021Review
- Oligodendrocytes Death Induced Sensorimotor and Cognitive Deficit in N-nitro-L-arginine methyl Rat Model of Pre-eclampsia.Neurochemical research · 2020Article
- Optogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response.Scientific reports · 2018Article
- Disrupted Spontaneous Neural Activity Related to Cognitive Impairment in Postpartum Women.Frontiers in psychology · 2018Article
- Functional Connectivity Mapping in the Animal Model: Principles and Applications of Resting-State fMRI.Frontiers in neurology · 2017Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although pregnancy-induced hormonal changes have been shown to alter the brain at the neuronal level, the exact effects of pregnancy on brain at the tissue level remain unclear. In this study, diffusion tensor imaging (DTI) and resting-state functional MRI (rsfMRI) were employed to investigate and document the effects of pregnancy on the structure and function of the brain tissues. Fifteen Sprague-Dawley female rats were longitudinally studied at three days before mating (baseline) and seventeen days after mating (G17). G17 is equivalent to the early stage of the third trimester in humans. Seven age-matched nulliparous female rats served as non-pregnant controls and were scanned at the same time-points. For DTI, diffusivity was found to generally increase in the whole brain during pregnancy, indicating structural changes at microscopic levels that facilitated water molecular movement. Regionally, mean diffusivity increased more pronouncedly in the dorsal hippocampus while fractional anisotropy in the dorsal dentate gyrus increased significantly during pregnancy. For rsfMRI, bilateral functional connectivity in the hippocampus increased significantly during pregnancy. Moreover, fractional anisotropy increase in the dentate gyrus appeared to correlate with the bilateral functional connectivity increase in the hippocampus. These findings revealed tissue structural modifications in the whole brain during pregnancy, and that the hippocampus was structurally and functionally remodeled in a more marked manner.
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Registered trials
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