ArticleScientific reports2015
Antigen-dependent and -independent contributions to primary memory CD8 T cell activation and protection following infection.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- The Role and Safety of Aluminum Adjuvants in Childhood Vaccines.Pediatrics · 2026Review
- HIV- and cytomegalovirus-specific human memory CD8+ T cells are activated and expanded independent of co-stimulatory signaling by T-cell receptor-specific immunotherapeutics.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8Cell reports · 2025Article
- Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8Frontiers in immunology · 2025Article
- The intersection of influenza infection and autoimmunity.Frontiers in immunology · 2025Review
- When inflammatory stressors dramatically change, disease phenotypes may transform between autoimmune hematopoietic failure and myeloid neoplasms.Frontiers in immunology · 2024Review
- Significance of bystander T cell activation in microbial infection.Nature immunology · 2022Review
- Article
- Article
- The activation of bystander CD8Experimental & molecular medicine · 2019Review
- Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies.Journal of immunology research · 2019Review
- Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies.Nature communications · 2018Article
- Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Past Life and Future Effects-How Heterologous Infections Alter Immunity to Influenza Viruses.Frontiers in immunology · 2018Review
- Time and Antigen-Stimulation History Influence Memory CD8 T Cell Bystander Responses.Frontiers in immunology · 2017Article
- Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity.Critical reviews in immunology · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Memory CD8 T-cell activation, including expression of IFN-γ and granzymeB, can be induced by antigen (Ag)-dependent signals through the T-cell-receptor, or by pathogen-derived inflammatory cytokines in an Ag-independent manner. Recent studies have come to conflicting results regarding the contributions of Ag and/or inflammation to memory CD8 T-cell activation. Additionally, research has indicated that inflammation-driven CD8 T-cell responses during un-related infections (bystander activation) have the potential to provide protection, but whether protection occurs in immuno-competent hosts is unclear. To investigate these questions, we examined activation of virus-specific memory CD8 T-cells following infection with L. monocytogenes either expressing or not cognate Ag. We show that Ag and inflammation act synergistically in vitro to induce memory activation. In vivo, we found that when memory CD8 T-cells significantly contribute to clearance of infection, early activation and continued responses by these cells are enhanced by cognate Ag recognition. Mechanistically, we show that bystander responses by memory are dependent upon the dose of infection and the amount of inflammation elicited following infection and are able to provide protection in IFN-γ deficient mice, but not in immuno-competent hosts. The data elucidate the requirements for memory CD8 T-cell activation and the protective role of bystander responses.
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Registered trials
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