Evidence map›Paper›PMID 26658220›Full record

ArticleJournal of clinical pathology2016

Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm.

Wan-Hsiang Hu, Katsumi Miyai, Judith C Sporn, Linda Luo, Jean Y J Wang, Bard Cosman, Sonia Ramamoorthy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Wan-Hsiang HuDepartment of Surgery, University of California San Diego Health System, San Diego, California, USA Rebecca and John Moores Cancer Center, University of California San Diego Health System, San Diego, California, USA Department of Colorectal Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Katsumi MiyaiDepartment of Pathology, School of Medicine, University of California, San Diego, California, USA.
Judith C SpornDepartment of General Surgery, Baystate Medical Center, Springfield, Massachusetts, USA.
Linda LuoDepartment of Surgery, University of California San Diego Health System, San Diego, California, USA Rebecca and John Moores Cancer Center, University of California San Diego Health System, San Diego, California, USA.
Jean Y J WangRebecca and John Moores Cancer Center, University of California San Diego Health System, San Diego, California, USA Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California, San Diego, California, USA.
Bard CosmanDepartment of Surgery, University of California San Diego Health System, San Diego, California, USA Department of Surgery, Veteran's Administration Medical Center, University of California, San Diego Healthcare System, San Diego, California, USA.
Sonia RamamoorthyDepartment of Surgery, University of California San Diego Health System, San Diego, California, USA Rebecca and John Moores Cancer Center, University of California San Diego Health System, San Diego, California, USA.
University of California, San Diego · USUC San Diego Health System · USBaystate Medical Center · US

Funding

STRUCTURE AND FUNCTION OF THE C-ABL PROTO-ONCOPROTEINR01CA043054 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, JEAN Y.J. · 1986 to 2018
$4.4M
NCI NIH HHS R01 CA043054
6 · The paper itself

Abstract

aimsThe macroH2A histone variants are epigenetic marks for inactivated chromatin. In this study, we examined the expression of macroH2A2 in anal neoplasm from anal intraepithelial neoplasia (AIN) to anal squamous cell carcinoma (SCC).

methodsAIN and anal SCC samples were analysed for macroH2A2 expression, HIV and human papilloma virus (HPV). The association of macroH2A2 expression with clinical grade, disease recurrence, overall survival and viral involvement was determined.

resultsmacroH2A2 was expressed in normal squamous tissue and lower grade AIN (I and II). Expression was lost in 38% of high-grade AIN (III) and 71% of anal SCC (p=0.002). Patients with AIN with macroH2A2-negative lesions showed earlier recurrence than those with macroH2A2-positive neoplasm (p=0.017). With anal SCC, macroH2A2 loss was more prevalent in the HPV-negative tumours.

conclusionsLoss of histone variant macroH2A2 expression is associated with the progression of anal neoplasm and can be used as a prognostic biomarker for high-grade AIN and SCC.

Indexed as

AdultAnus NeoplasmsCarcinoma in SituCarcinoma, Squamous CellDisease ProgressionFemaleHistonesHumansMaleMiddle AgedPapillomaviridaePapillomavirus InfectionsHistonesmacroH2A histoneANUSCANCERHIVHPV

Identifiers

PMID26658220
PMCPMC4941135
OpenAlexW2273494019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.