ArticleDevelopmental biology2016
miR-430 regulates oriented cell division during neural tube development in zebrafish.
Article in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Decoding the RNA Regulatory Network in Medaka (Animals : an open access journal from MDPI · 2026Article
- Advances in miRNA research: Unraveling the complexities of gene regulation.Animal models and experimental medicine · 2025Review
- Regulation of MicroRNAs After Spinal Cord Injury in Adult Zebrafish.Journal of molecular neuroscience : MN · 2024Article
- A maternal-to-zygotic-transition gene block on the zebrafish sex chromosome.G3 (Bethesda, Md.) · 2024Article
- miR-430 regulates zygotic mRNA during zebrafish embryogenesis.Genome biology · 2024Article
- Optical Control of MicroRNA Function in Zebrafish Embryos.Journal of the American Chemical Society · 2022Article
- Characterization of miRNAs in Embryonic, Larval, and Adult Lumpfish Provides a Reference miRNAome forBiology · 2022Article
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- Genetic Deletion ofFrontiers in genetics · 2020Article
- Dissecting the mechanisms of cell division.The Journal of biological chemistry · 2019Review
- Review
- Article
- Inventory of European Sea Bass (Frontiers in genetics · 2019Article
- High resolution annotation of zebrafish transcriptome using long-read sequencing.Genome research · 2018Article
- Article
- The zebrafish miR-125c is induced under hypoxic stressOncotarget · 2017Article
- miR-326 Inhibits Gastric Cancer Cell Growth Through Downregulating NOB1.Oncology research · 2017Article
- Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition.Genome research · 2017Article
- Transcriptome-wide microRNA and target dynamics in the fat body during the gonadotrophic cycle ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development.The EMBO journal · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
MicroRNAs have emerged as critical regulators of gene expression. Originally shown to regulate developmental timing, microRNAs have since been implicated in a wide range of cellular functions including cell identity, migration and signaling. miRNA-430, the earliest expressed microRNA during zebrafish embryogenesis, is required to undergo morphogenesis and has previously been shown to regulate maternal mRNA clearance, Nodal signaling, and germ cell migration. The functions of miR-430 in brain morphogenesis, however, remain unclear. Herein we find that miR-430 instructs oriented cell divisions in the neural rod required for neural midline formation. Loss of miR-430 function results in mitotic spindle misorientation in the neural rod, failed neuroepithelial integration after cell division, and ectopic cell accumulation in the dorsal neural tube. We propose that miR-430, independently of canonical apicobasal and planar cell polarity (PCP) pathways, coordinates the stereotypical cell divisions that instruct neural tube morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.